A. Cousido-Siah

Structure of the E6/E6AP/p53 complex required for HPV-mediated degradation of p53

Denise Martinez-Zapien, Francesc X. Ruiz, Juline Poirson et al. · Nature · 2016 · 469 citations · Full text

E6/e6ap/p53 Complex, Molecular Biology, Cell Death +6

Modulation of Aldose Reductase Inhibition by Halogen Bond Tuning

Jindřich Fanfrlík, Michal H. Kolář, Martin Kamlar et al. · ACS Chemical Biology · 2013 · 93 citations · Full text

Discovery of (<i>R</i>)-2-Amino-6-borono-2-(2-(piperidin-1-yl)ethyl)hexanoic Acid and Congeners As Highly Potent Inhibitors of Human Arginases I and II for Treatment of Myocardial Reperfusion Injury

M.C. Van Zandt, Darren L. Whitehouse, Adam Gołȩbiowski et al. · Journal of Medicinal Chemistry · 2013 · 84 citations · Full text

Lead Compounds, Pharmaceutical Science, Cardiovascular Pharmacology +19

Quantum model of catalysis based on a mobile proton revealed by subatomic x-ray and neutron diffraction studies of h-aldose reductase

Matthew P. Blakeley, Federico M. Ruiz, Raúl E. Cachau et al. · Proceedings of the National Academy of Sciences · 2008 · 80 citations · Full text

Engineering, Aldo-keto Reductase, Hydrogen Bond Network +21

A novel small-molecule inhibitor of the human papillomavirus E6-p53 interaction that reactivates p53 function and blocks cancer cells growth

Marta Celegato, Lorenzo Messa, Laura Goracci et al. · Cancer Letters · 2019 · 76 citations

Tumor Biology, P53 Function, Medicine +10