Tetramerization Dynamics of C-terminal Domain Underlies Isoform-specific cAMP Gating in Hyperpolarization-activated Cyclic Nucleotide-gated Channels

Marco Lolicato, Marco Nardini, Sabrina Gazzarrini, +10

Journal of Biological Chemistry

Biophysical ModelingMolecular BiologyTetramerization DynamicsOptogeneticsCellular Physiology +16

Parkinson-related LRRK2 mutation R1441C/G/H impairs PKA phosphorylation of LRRK2 and disrupts its interaction with 14-3-3

Kathrin Muda, Daniela Bertinetti, Frank Gesellchen, +7

Proceedings of the National Academy of Sciences

Structure-Guided Design of Selective Epac1 and Epac2 Agonists

Frank Schwede, Daniela Bertinetti, Carianne N. Langerijs, +9

PLoS Biology

Divalent Metal Ions Mg²⁺ and Ca²⁺ Have Distinct Effects on Protein Kinase A Activity and Regulation

Matthias J. Knape, Lalima G. Ahuja, Daniela Bertinetti, +4

ACS Chemical Biology

Molecular BiologyComplex FormationChemical BiologyCellular PhysiologyBiological Inorganic Chemistry +15

Isoform-Selective Disruption of AKAP-Localized PKA Using Hydrocarbon Stapled Peptides

Yuxiao Wang, Tienhuei G. Ho, Daniela Bertinetti, +9

ACS Chemical Biology

A-kinase Anchoring ProteinsProtein Kinase ASignal TransductionSignaling PathwayBiochemistry +13

Structural Basis for Cyclic-Nucleotide Selectivity and cGMP-Selective Activation of PKG I

Gilbert Y. Huang, Jeong Joo Kim, Albert S. Reger, +12

Structure

Signal TransductionMolecular PhysiologyBiochemistryG Protein-coupled ReceptorNatural Sciences +9

The Pseudomonas aeruginosa Chemotaxis Methyltransferase CheR1 Impacts on Bacterial Surface Sampling

Juliane Schmidt, Mathias Müsken, Tanja Becker, +6

PLoS ONE

BiofilmsMethyl GroupVirulence FactorBacteriologyChemotaxis Impact +10

Divalent metal ions control activity and inhibition of protein kinases

Matthias J. Knape, Mike Ballez, Nicole C. G. Burghardt, +4

Metallomics

Binding of the Human 14-3-3 Isoforms to Distinct Sites in the Leucine-Rich Repeat Kinase 2

Jascha T. Manschwetus, Maximilian Wallbott, Alexandra Fachinger, +5

Frontiers in Neuroscience

Molecular RegulationMolecular Biology14-3-3 IsoformsPeptide Science14-3-3 Binding Site +17

A PKA inhibitor motif within SMOOTHENED controls Hedgehog signal transduction

John T. Happ, Corvin D. Arveseth, Jessica Bruystens, +16

Nature Structural & Molecular Biology

Hedgehog Signal TransductionDevelopmental BiologyMolecular PhysiologySignal TransductionSignaling Pathway +5