Rubén Tommasi

Tipranavir (PNU-140690):  A Potent, Orally Bioavailable Nonpeptidic HIV Protease Inhibitor of the 5,6-Dihydro-4-hydroxy-2-pyrone Sulfonamide Class

Steve R. Turner, Joseph W. Strohbach, Rubén Tommasi et al. · Journal of Medicinal Chemistry · 1998 · 296 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

ETX2514 is a broad-spectrum β-lactamase inhibitor for the treatment of drug-resistant Gram-negative bacteria including Acinetobacter baumannii

Thomas F. Durand-Réville, Satenig Guler, Janelle Comita-Prevoir et al. · Nature Microbiology · 2017 · 271 citations

Life Sciences, Infectious Diseases, Microbiology +16

Trends and Exceptions of Physical Properties on Antibacterial Activity for Gram-Positive and Gram-Negative Pathogens

Dean G. Brown, Tricia L. May‐Dracka, Moriah M. Gagnon et al. · Journal of Medicinal Chemistry · 2014 · 255 citations

Pharmacy, Pharmacology, Drug Design +13

Human HDAC isoform selectivity achieved via exploitation of the acetate release channel with structurally unique small molecule inhibitors

Lewis Whitehead, Markus Dobler, Branko Radetich et al. · Bioorganic & Medicinal Chemistry · 2011 · 156 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +10

Rational design of a new antibiotic class for drug-resistant infections

Thomas F. Durand-Réville, Alita A. Miller, John P. O’Donnell et al. · Nature · 2021 · 140 citations

Life Sciences, Infectious Diseases, Medicinal Chemistry +16