Rubén Tommasi

Tipranavir (PNU-140690):  A Potent, Orally Bioavailable Nonpeptidic HIV Protease Inhibitor of the 5,6-Dihydro-4-hydroxy-2-pyrone Sulfonamide Class

Steve R. Turner, Joseph W. Strohbach, Rubén Tommasi et al. · Journal of Medicinal Chemistry · 1998 · 293 citations · Full text

ETX2514 is a broad-spectrum β-lactamase inhibitor for the treatment of drug-resistant Gram-negative bacteria including Acinetobacter baumannii

Thomas F. Durand-Réville, Satenig Guler, Janelle Comita-Prevoir et al. · Nature Microbiology · 2017 · 262 citations

Bacterial Resistance, Antimicrobial Susceptibility, Health Sciences +12

Trends and Exceptions of Physical Properties on Antibacterial Activity for Gram-Positive and Gram-Negative Pathogens

Dean G. Brown, Tricia L. May‐Dracka, Moriah M. Gagnon et al. · Journal of Medicinal Chemistry · 2014 · 249 citations

Antibacterial Activity, Polar Compounds, Antimicrobial Chemotherapy +20

Human HDAC isoform selectivity achieved via exploitation of the acetate release channel with structurally unique small molecule inhibitors

Lewis Whitehead, Markus Dobler, Branko Radetich et al. · Bioorganic & Medicinal Chemistry · 2011 · 153 citations · Full text

Biochemistry, Natural Sciences, Medicine +7

Identification of Dipeptidyl Nitriles as Potent and Selective Inhibitors of Cathepsin B through Structure-Based Drug Design

Paul D. Greenspan, Kirk Clark, Rubén Tommasi et al. · Journal of Medicinal Chemistry · 2001 · 136 citations · Full text