Ann De Blieck

Discovery of<i>N</i>-(3-Carbamoyl-5,5,7,7-tetramethyl-5,7-dihydro-4<i>H</i>-thieno[2,3-<i>c</i>]pyran-2-yl)-l<i>H</i>-pyrazole-5-carboxamide (GLPG1837), a Novel Potentiator Which Can Open Class III Mutant Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Channels to a High Extent

Steven E. Van der Plas, Hans Kelgtermans, Tom De Munck et al. · Journal of Medicinal Chemistry · 2017 · 58 citations · Full text

One-pot tandem 1,4–1,2-addition of phosphites to quinolines

Ann De Blieck, Kurt G. R. Masschelein, Fréderic Dhaene et al. · Chemical Communications · 2009 · 33 citations

Inorganic Chemistry, Engineering, One-pot Tandem 1,4–1,2-Addition +9

A safe production method for acetone cyanohydrin

Thomas S. A. Heugebaert, Bart I. Roman, Ann De Blieck et al. · Tetrahedron Letters · 2010 · 28 citations

Engineering, Biotechnology, Acetone Cyanohydrin +2

Diphosphonylation of Aromatic Diazaheterocycles and Theoretical Rationalization of Product Yields

Ann De Blieck, Şaron Çatak, Wouter Debrouwer et al. · European Journal of Organic Chemistry · 2013 · 25 citations

Derivative (Chemistry), Engineering, Heterocyclic +12

Discovery of GLPG2451, a Novel Once Daily Potentiator for the Treatment of Cystic Fibrosis

Steven E. Van der Plas, Hans Kelgtermans, Oscar Mammoliti et al. · Journal of Medicinal Chemistry · 2021 · 22 citations · Full text

Signal Transduction, G Protein-coupled Receptor, Medicine +10