Jamie B. Spangler

De novo design of potent and selective mimics of IL-2 and IL-15

Daniel‐Adriano Silva, Shawn Yu, Umut Y. Ulge et al. · Nature · 2019 · 524 citations · Full text

Cytokine, Medicine, Selective Mimics +6

Antibodies to Interleukin-2 Elicit Selective T Cell Subset Potentiation through Distinct Conformational Mechanisms

Jamie B. Spangler, Jakub Tomala, Vincent C. Luca et al. · Immunity · 2015 · 214 citations · Full text

Inflammation, Distinct Conformational Mechanisms, Autoimmune Disease +13

Interleukin-2 Activity Can Be Fine Tuned with Engineered Receptor Signaling Clamps

Suman Mitra, Aaron M. Ring, Shoba Amarnath et al. · Immunity · 2015 · 174 citations · Full text

Inflammation, Cytokine, Molecular Immunology +10

Structural basis for IL-12 and IL-23 receptor sharing reveals a gateway for shaping actions on T versus NK cells

Caleb R. Glassman, Yamuna Kalyani Mathiharan, Kevin M. Jude et al. · Cell · 2021 · 167 citations · Full text

Autoimmune Disease, Il-23 Receptor, T-regulatory Cell +11

Combination antibody treatment down-regulates epidermal growth factor receptor by inhibiting endosomal recycling

Jamie B. Spangler, Jason R. Neil, Sivan Abramovitch et al. · Proceedings of the National Academy of Sciences · 2010 · 154 citations · Full text