Alem W. Kahsai

GPCR-G Protein-β-Arrestin Super-Complex Mediates Sustained G Protein Signaling

A. Thomsen, Bianca Plouffe, Thomas J. Cahill et al. · Cell · 2016 · 553 citations · Full text

Protein Function, Signal Transduction, Molecular Physiology +8

Visualization of arrestin recruitment by a G-protein-coupled receptor

Arun K. Shukla, Gerwin Westfield, Kunhong Xiao et al. · Nature · 2014 · 498 citations

Arrestin Recruitment, Signal Transduction, G Protein-coupled Receptor +6

Distinct conformations of GPCR–β-arrestin complexes mediate desensitization, signaling, and endocytosis

Thomas J. Cahill, A. Thomsen, Jeffrey Tarrasch et al. · Proceedings of the National Academy of Sciences · 2017 · 374 citations · Full text

Molecular Regulation, Molecular Biology, Tail Conformation +18

Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation

Dean P. Staus, Ryan T. Strachan, Aashish Manglik et al. · Nature · 2016 · 327 citations · Full text

Signal Transduction, Molecular Physiology, Biochemistry +12

Multiple ligand-specific conformations of the β2-adrenergic receptor

Alem W. Kahsai, Kunhong Xiao, Sudarshan Rajagopal et al. · Nature Chemical Biology · 2011 · 248 citations · Full text

Molecular Pharmacology, Signal Transduction, Molecular Physiology +9