GPCR-G Protein-β-Arrestin Super-Complex Mediates Sustained G Protein Signaling

A. Thomsen, Bianca Plouffe, Thomas J. Cahill, +14

Cell

Protein FunctionSignal TransductionMolecular PhysiologySignaling PathwayG Protein-coupled Receptor +6

Visualization of arrestin recruitment by a G-protein-coupled receptor

Arun K. Shukla, Gerwin Westfield, Kunhong Xiao, +26

Nature

Arrestin RecruitmentSignal TransductionG Protein-coupled ReceptorMedicineFunctional Selectivity +4

Distinct conformations of GPCR–β-arrestin complexes mediate desensitization, signaling, and endocytosis

Thomas J. Cahill, A. Thomsen, Jeffrey Tarrasch, +24

Proceedings of the National Academy of Sciences

Molecular RegulationMolecular BiologyTail ConformationSynaptic SignalingCore Conformation +16

Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation

Dean P. Staus, Ryan T. Strachan, Aashish Manglik, +15

Nature

Signal TransductionMolecular PhysiologyBiochemistryG Protein-coupled ReceptorMedicine +10

Multiple ligand-specific conformations of the β2-adrenergic receptor

Alem W. Kahsai, Kunhong Xiao, Sudarshan Rajagopal, +5

Nature Chemical Biology

Molecular PharmacologySignal TransductionMolecular PhysiologyG Protein-coupled ReceptorMedicine +7

Mechanism of intracellular allosteric β2AR antagonist revealed by X-ray crystal structure

Xiangyu Liu, Seungkirl Ahn, Alem W. Kahsai, +10

Nature

X-ray CrystallographyMolecular PharmacologyBiochemistryMedicineNatural Sciences +7

Allosteric “beta-blocker” isolated from a DNA-encoded small molecule library

Seungkirl Ahn, Alem W. Kahsai, Biswaranjan Pani, +22

Proceedings of the National Academy of Sciences

Mechanism of β ₂ AR regulation by an intracellular positive allosteric modulator

Xiangyu Liu, Ali Masoudi, Alem W. Kahsai, +11

Science

Arrestin-biased AT1R agonism induces acute catecholamine secretion through TRPC3 coupling

Chunhua Liu, Zheng Gong, Zong-Lai Liang, +24

Nature Communications

Noncanonical scaffolding of G _αi and β-arrestin by G protein–coupled receptors

Jeffrey S. Smith, Thomas F. Pack, Asuka Inoue, +15

Science