Cryo-EM structure of the activated GLP-1 receptor in complex with a G protein

Yan Zhang, Bingfa Sun, Dan Feng, +8

Nature

Protein FunctionMolecular PhysiologySignal TransductionActivated Glp-1 ReceptorG Protein-coupled Receptor +11

GPCR-G Protein-β-Arrestin Super-Complex Mediates Sustained G Protein Signaling

A. Thomsen, Bianca Plouffe, Thomas J. Cahill, +14

Cell

Protein FunctionSignal TransductionMolecular PhysiologySignaling PathwayG Protein-coupled Receptor +6

Phase-plate cryo-EM structure of a class B GPCR–G-protein complex

Yi-Lynn Liang, Maryam Khoshouei, Mazdak Radjainia, +15

Nature

Protein X-ray CrystallographyMolecular BiologyPhase-plate Cryo-em StructureCrystallographyStructural Biology

Distinct conformations of GPCR–β-arrestin complexes mediate desensitization, signaling, and endocytosis

Thomas J. Cahill, A. Thomsen, Jeffrey Tarrasch, +24

Proceedings of the National Academy of Sciences

Molecular RegulationMolecular BiologyTail ConformationSynaptic SignalingCore Conformation +16

Structural insights into the activation of metabotropic glutamate receptors

Antoine Koehl, Hongli Hu, Dan Feng, +14

Nature

MedicineNeurotransmitterNeuropharmacologyNeuroscienceMolecular Neurobiology +2

Structures of two distinct conformations of holo-non-ribosomal peptide synthetases

Eric J. Drake, Bradley R. Miller, Ce Shi, +6

Nature

Holo-non-ribosomal Peptide SynthetasesMolecular BiologyConformational StudyPeptide SynthesisMedicine +2

Extended surface for membrane association in Zika virus NS1 structure

William Clay Brown, David L. Akey, Jamie R. Konwerski, +4

Nature Structural & Molecular Biology

Virus StructureExtended SurfacePathogenesisViral PathogenesisMolecular Biology +7

Phosphoantigen-induced conformational change of butyrophilin 3A1 (BTN3A1) and its implication on Vγ9Vδ2 T cell activation

Siyi Gu, Joseph R. Sachleben, Christopher T. Boughter, +5

Proceedings of the National Academy of Sciences

Mechanism of Vps4 hexamer function revealed by cryo-EM

Min Su, Emily Z. Guo, Xinqiang Ding, +5

Science Advances

Highly Branched Pentasaccharide-Bearing Amphiphiles for Membrane Protein Studies

Muhammad Ehsan, Yang Du, Nicola J. Scull, +9

Journal of the American Chemical Society

Pentasaccharide-bearing AmphiphilesProteinlipid InteractionMembrane FormationEngineeringBiochemistry +9