Systemic Gene Expression After Intravenous DNA Delivery into Adult Mice

Ning Zhu, Denny Liggitt, Yong Liu, +1

Science

In Vivo Gene TherapyImmunologyTissue TransplantationGene DeliveryBiomedical Engineering +14

Recognition of the Peripheral Self by Naturally Arising CD25+ CD4+ T Cell Receptors

Chyi‐Song Hsieh, Yuqiong Liang, Aaron J. Tyznik, +3

Immunity

Signal TransductionAutoimmune DiseaseT-regulatory CellImmunologyPeripheral Self +6

A Pathogenic Role for Myelin-Specific Cd8+ T Cells in a Model for Multiple Sclerosis

Eric S. Huseby, Denny Liggitt, Thea Brabb, +3

The Journal of Experimental Medicine

Differential regulation of central nervous system autoimmunity by TH1 and TH17 cells

Ingunn M. Stromnes, Lauren Cerretti, Denny Liggitt, +2

Nature Medicine

InflammationAutoimmune DiseaseImmune Cell DevelopmentMedicineT-regulatory Cell +9

Targeted disruption of the low-affinity leukemia inhibitory factor receptor gene causes placental, skeletal, neural and metabolic defects and results in perinatal death

Carol B. Ware, Mark C. Horowitz, Blair R. Renshaw, +16

Development

Mixed-phenotype Acute LeukemiaApoptosisCell DeathPerinatal DeathOsteoporosis +15

Humoral immune responses in CD40 ligand-deficient mice.

Blair R. Renshaw, William C. Fanslow, Richard J. Armitage, +5

The Journal of Experimental Medicine

Functional Cd40 LigandAutoimmune DiseaseAllergySelective DeficienciesMedicine +13

CD4+ T cells that express high levels of CD45RB induce wasting disease when transferred into congenic severe combined immunodeficient mice. Disease development is prevented by cotransfer of purified CD4+ T cells.

Philip Morrissey, K Charrier, S Braddy, +2

The Journal of Experimental Medicine

Cd4+ CellsLymphocyte DevelopmentImmunologyPathologyImmunologic Mechanism +16

Insulin-dependent diabetes mellitus induced in transgenic mice by ectopic expression of class II MHC and interferon-gamma

Nora Sarvetnick, Denny Liggitt, Sharon Pitts, +2

Cell

ImmunogeneticsAutoimmune DiseaseClass Ii MhcDiabetesImmunology +9

Cellular Mechanisms of Fatal Early-Onset Autoimmunity in Mice with the T Cell-Specific Targeting of Transforming Growth Factor-β Receptor

Julien C. Marie, Denny Liggitt, Alexander Y. Rudensky

Immunity

Fatal Early-onset AutoimmunityCellular MechanismsAutoimmune DiseaseImmune DysregulationImmune Cell Development +13

Loss of pancreatic islet tolerance induced by β-cell expression of interferon-γ

Nora Sarvetnick, Judith A. Shizuru, Denny Liggitt, +5

Nature

Pancreatic Islet ToleranceSignal TransductionDiabetesImmunologyPancreatic Islet Biology +8