Herbert Yajima

Asymmetric Synthesis of Akt Kinase Inhibitor Ipatasertib

Chong Han, Scott Savage, Mohammad H. Al‐Sayah et al. · Organic Letters · 2017 · 46 citations

Organic Chemistry, Chemical Biology, Biosynthesis +17

A Practical Synthesis of a PI3K Inhibitor under Noncryogenic Conditions via Functionalization of a Lithium Triarylmagnesiate Intermediate

Qingping Tian, Zhigang Ken Cheng, Herbert Yajima et al. · Organic Process Research & Development · 2012 · 31 citations

Bioorganic Chemistry, Lithium Triarylmagnesiate Intermediate, Engineering +16

Synthesis of Akt Inhibitor Ipatasertib. Part 2. Total Synthesis and First Kilogram Scale-up

Travis Remarchuk, Frédéric St-Jean, Diane E. Carrera et al. · Organic Process Research & Development · 2014 · 26 citations

Chiral Intermediates, Akt Inhibitor Ipatasertib, Chemical Biology +19

Palladium-Catalyzed α-Arylation of Sultams with Aryl and Heteroaryl Iodides

Olivier René, Benjamin P. Fauber, Sushant Malhotra et al. · Organic Letters · 2014 · 21 citations

Chemical Engineering, Engineering, Palladium-catalyzed α-Arylation +9

Development of an Efficient, Safe, and Environmentally Friendly Process for the Manufacture of GDC-0084

Andreas Stumpf, Andrew McClory, Herbert Yajima et al. · Organic Process Research & Development · 2016 · 18 citations

Engineering, Organic Chemistry, Chemistry +20