MLN64 mediates egress of cholesterol from endosomes to mitochondria in the absence of functional Niemann-Pick Type C1 protein

Mark Charman, Barry E. Kennedy, Nolan Osborne, +1

Journal of Lipid Research

GeneticsMolecular BiologyMitochondrial BiologyOxidative StressEndocytic Pathway +14

Autophagic homeostasis is required for the pluripotency of cancer stem cells

Tanveer Sharif, Emma Martell, Cathleen Dai, +6

Autophagy

Cancer BiologyAutophagic HomeostasisTumor BiologyCell AutophagySignaling Pathway +18

TRPM2 channel–mediated regulation of autophagy maintains mitochondrial function and promotes gastric cancer cell survival via the JNK-signaling pathway

Shekoufeh Almasi, Barry E. Kennedy, Mariam Elaghil, +4

Journal of Biological Chemistry

Cell AutophagyMitophagySignal TransductionSignaling PathwayJnk-signaling Pathway +8

Adaptations of Energy Metabolism Associated with Increased Levels of Mitochondrial Cholesterol in Niemann-Pick Type C1-deficient Cells

Barry E. Kennedy, Corina T. Madreiter‐Sokolowski, Neelanjan Vishnu, +3

Journal of Biological Chemistry

Endosomal CholesterolEnergy MetabolismOxysterolBiochemistryMitochondrial Function +12

The NAD+ Salvage Pathway Supports PHGDH-Driven Serine Biosynthesis

J. Patrick Murphy, Michael Giacomantonio, João A. Paulo, +9

Cell Reports

Niemann-Pick Type C2 protein contributes to the transport of endosomal cholesterol to mitochondria without interacting with NPC1

Barry E. Kennedy, Mark Charman, Barbara Karten

Journal of Lipid Research

Pre-Symptomatic Activation of Antioxidant Responses and Alterations in Glucose and Pyruvate Metabolism in Niemann-Pick Type C1-Deficient Murine Brain

Barry E. Kennedy, Véronique Leblanc, Tiffany M. Mailman, +4

PLoS ONE

MitophagyNeurochemical BiomarkersPre-symptomatic ActivationAntioxidant ResponsesOxidative Stress +20

RTN4 Knockdown Dysregulates the AKT Pathway, Destabilizes the Cytoskeleton, and Enhances Paclitaxel-Induced Cytotoxicity in Cancers

Gopal P. Pathak, Rashmi R. Shah, Barry E. Kennedy, +7

Molecular Therapy

Human Brain Chemokine and Cytokine Expression in Sepsis: A Report of Three Cases

Jordan Warford, Anna-Claire Lamport, Barry E. Kennedy, +1

Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques

TAp73 Modifies Metabolism and Positively Regulates Growth of Cancer Stem–Like Cells in a Redox-Sensitive Manner

Tanveer Sharif, Cathleen Dai, Emma Martell, +10

Clinical Cancer Research