A De Novo Protein Binding Pair By Computational Design and Directed Evolution

John Karanicolas, Jacob E. Corn, Irwin Chen, +12

Molecular Cell

Structural BioinformaticsProtein FoldingNatural SciencesDirected EvolutionComputational Biology +10

An early-life microbiota metabolite protects against obesity by regulating intestinal lipid metabolism

Catherine Shelton, E. L. Sing, Jessica Mo, +18

Cell Host & Microbe

NutritionDysbiosisHost-microbe InteractionsProbioticsObesity +23

Whole Transcriptome Analysis of Notochord-Derived Cells during Embryonic Formation of the Nucleus Pulposus

Sun H. Peck, Kendra McKee, John W. Tobias, +3

Scientific Reports

Directed Evolution of a Small-Molecule-Triggered Intein with Improved Splicing Properties in Mammalian Cells

Sun H. Peck, Irwin Chen, David R. Liu

Chemistry & Biology

Transcriptional RegulationSmall-molecule-triggered InteinMedicineNatural SciencesDirected Evolution +8

The Role of N-Glycosylation in Folding, Trafficking, and Functionality of Lysosomal Protein CLN5

Akshay Moharir, Sun H. Peck, Theodore Budden, +1

PLoS ONE

Protein FunctionCln5 RetentionProtein AssemblyBiochemistryProtein Folding +13

Hypoxic Preconditioning Enhances Bone Marrow–Derived Mesenchymal Stem Cell Survival in a Low Oxygen and Nutrient-Limited 3D Microenvironment

Sun H. Peck, Justin R. Bendigo, John W. Tobias, +4

Cartilage

RNA sequencing identifies gene regulatory networks controlling extracellular matrix synthesis in intervertebral disk tissues

Scott M. Riester, Lin Yang, Wei Wang, +16

Journal of Orthopaedic Research®

Delayed hypertrophic differentiation of epiphyseal chondrocytes contributes to failed secondary ossification in mucopolysaccharidosis VII dogs

Sun H. Peck, Philip J. O’Donnell, Jennifer L. Kang, +6

Molecular Genetics and Metabolism

Regenerative MedicineMechanobiologyDevelopmental BiologyBone Morphogenic ProteinMedicine +9

Quantitative MRI correlates with histological grade in a percutaneous needle injury mouse model of disc degeneration

Matthew Piazza, Sun H. Peck, Sarah E. Gullbrand, +6

Journal of Orthopaedic Research®

Intervertebral DiscPeripheral Nerve InjuryPain MedicineDisc RegenerationBiomedical Engineering +21

Effects of nanocrystalline hydroxyapatite concentration and skeletal site on bone and cartilage formation in rats

Lauren A. Boller, Stefanie M. Shiels, David C. Florian, +5

Acta Biomaterialia

MechanobiologyTissue EngineeringNanocrystalline Hydroxyapatite ConcentrationEngineeringHydroxyapatite +10