Nrf2-Mediated Fibroblast Reprogramming Drives Cellular Senescence by Targeting the Matrisome

Paul Hiebert, Mateusz S. Wietecha, Michael Cangkrama, +11

Developmental Cell

FibrosisCellular SenescenceCell ProliferationFibroblast Growth FactorSystems Biology +3

Genome Editing of Human Primary Keratinocytes by CRISPR/Cas9 Reveals an Essential Role of the NLRP1 Inflammasome in UVB Sensing

Gabriele Fenini, Serena Grossi, Emmanuel Contassot, +4

Journal of Investigative Dermatology

Off-target EffectNatural SciencesHuman Primary KeratinocytesMolecular BiologyGenome Engineering +7

Caspase-1 Activity Is Required for UVB-Induced Apoptosis of Human Keratinocytes

Gabriel Sollberger, Gerhard E. Strittmatter, Serena Grossi, +4

Journal of Investigative Dermatology

Signal TransductionCell RegulationPhotocarcinogenesisApoptosisCaspase-1 Activity Is +6

The <scp>A</scp>rabidopsis <scp>STRESS RESPONSE SUPPRESSOR DEAD</scp>‐box <scp>RNA</scp> helicases are nucleolar‐ and chromocenter‐localized proteins that undergo stress‐mediated relocalization and are involved in epigenetic gene silencing

Asif Ali Khan, Anna Garbelli, Serena Grossi, +10

The Plant Journal

IDUA mutational profiling of a cohort of 102 European patients with mucopolysaccharidosis type I: identification and characterization of 35 novel α-L-iduronidase (IDUA) alleles

Francesca Bertola, Mirella Filocamo, Giorgio Casati, +20

Human Mutation

EngineeringIdua Mutational ProfilingGeneticsGenetic EpidemiologyPathology +20

Opposing effects of Nrf2 and Nrf2‐activating compounds on the NLRP3 inflammasome independent of Nrf2‐mediated gene expression

Martha Garstkiewicz, Gerhard E. Strittmatter, Serena Grossi, +5

European Journal of Immunology

Cell Line and DNA Biobank From Patients Affected by Genetic Diseases

Mirella Filocamo, Raffaella Mazzotti, Fabio Corsolini, +8

Open Journal of Bioresources

Genetic TestingEngineeringPatients AffectedGeneticsDna Analysis +26

Functional analysis of 11 novel GBA alleles

Erika Malini, Serena Grossi, Marta Deganuto, +8

European Journal of Human Genetics

BiologyGenetic AnalysisAllelic VariantMolecular EcologyGenetics +5

Human iPSC-based models highlight defective glial and neuronal differentiation from neural progenitor cells in metachromatic leukodystrophy

Giacomo Frati, Marco Luciani, Vasco Meneghini, +9

Cell Death and Disease

Molecular Genetic Analysis of the PLP1 Gene in 38 Families with PLP1-related disorders: Identification and Functional Characterization of 11 Novel PLP1 Mutations

Serena Grossi, Stefano Regis, Roberta Biancheri, +15

Orphanet Journal of Rare Diseases