Nrf2-Mediated Fibroblast Reprogramming Drives Cellular Senescence by Targeting the Matrisome

Paul Hiebert, Mateusz S. Wietecha, Michael Cangkrama, +11

Developmental Cell

FibrosisCellular SenescenceCell ProliferationFibroblast Growth FactorSystems Biology +3

The unique and cooperative roles of the Grainy head-like transcription factors in epidermal development reflect unexpected target gene specificity

Yeliz Boglev, Tomasz Wilanowski, Jacinta Caddy, +7

Developmental Biology

Skin DevelopmentLineage PlasticityDevelopmental BiologyFunctional GenomicsGenetics +7

Activin-mediated alterations of the fibroblast transcriptome and matrisome control the biomechanical properties of skin wounds

Mateusz S. Wietecha, Marco Pensalfini, Michael Cangkrama, +5

Nature Communications

Tissue EngineeringEngineeringMatrix DepositionBiomechanical PropertiesBiomedical Engineering +17

Identification of a Novel Proto-oncogenic Network in Head and Neck Squamous Cell Carcinoma

Smitha R. Georgy, Michael Cangkrama, Seema Srivastava, +6

JNCI Journal of the National Cancer Institute

A paracrine activin A–mDia2 axis promotes squamous carcinogenesis via fibroblast reprogramming

Michael Cangkrama, Mateusz S. Wietecha, Nicolas Mathis, +7

EMBO Molecular Medicine

Integrated multi-omics reveals cellular and molecular interactions governing the invasive niche of basal cell carcinoma

Laura Yerly, Christine Pich-Bavastro, Jérémy Di Domizio, +6

Nature Communications

Activin promotes skin carcinogenesis by attraction and reprogramming of macrophages

Maria Antsiferova, Aleksandra Piwko‐Czuchra, Michael Cangkrama, +8

EMBO Molecular Medicine

Two Ancient Gene Families Are Critical for Maintenance of the Mammalian Skin Barrier in Postnatal Life

Michael Cangkrama, Charbel Darido, Smitha R. Georgy, +5

Journal of Investigative Dermatology

Skin DevelopmentDevelopmental BiologyCutaneous BiologyGeneticsPostnatal Life +6

A Protumorigenic mDia2–MIRO1 Axis Controls Mitochondrial Positioning and Function in Cancer-Associated Fibroblasts

Michael Cangkrama, Huan Liu, James Whipman, +6

Cancer Research

Phase-specific signatures of wound fibroblasts and matrix patterns define cancer-associated fibroblast subtypes

Mateusz S. Wietecha, David Lauenstein, Michael Cangkrama, +7

Matrix Biology

PathologyBioinformatics PipelineDermatologyCancer BiologyTumor Biology +17