BAP1 regulates IP3R3-mediated Ca2+ flux to mitochondria suppressing cell transformation

Angela Bononi, Carlotta Giorgi, Simone Patergnani, +22

Nature

Signal TransductionMitochondrial FunctionMitochondrial DynamicCell SignalingNatural Sciences +6

PTEN counteracts FBXL2 to promote IP3R3- and Ca2+-mediated apoptosis limiting tumour growth

Shafi Kuchay, Carlotta Giorgi, Daniele Simoneschi, +11

Nature

Cancer ResearchTumour GrowthMedicineApoptosisCell Death +7

μ-Calpain is essential for postmortem proteolysis of muscle proteins1,2

G.H. Geesink, Shafi Kuchay, Athar H. Chishti, +1

Journal of Animal Science

Muscle TissueMuscle FunctionCellular PhysiologyKinesiologyMuscle Injury +17

mTOR Generates an Auto-Amplification Loop by Triggering the βTrCP- and CK1α-Dependent Degradation of DEPTOR

Shanshan Duan, Jeffrey R. Skaar, Shafi Kuchay, +4

Molecular Cell

Signal TransductionBiochemistryNatural SciencesMolecular BiologyAuto-amplification Loop +1

KDM2A represses transcription of centromeric satellite repeats and maintains the heterochromatic state

David Frescas, Daniele Guardavaccaro, Shafi Kuchay, +6

Cell Cycle

Germline BAP1 mutations induce a Warburg effect

Angela Bononi, Haining Yang, Carlotta Giorgi, +15

Cell Death and Differentiation

FBXL2- and PTPL1-mediated degradation of p110-free p85β regulatory subunit controls the PI(3)K signalling cascade

Shafi Kuchay, Shanshan Duan, Emily Schenkein, +5

Nature Cell Biology

Signal TransductionSignaling PathwayCell RegulationMolecular RegulationNatural Sciences +10

GGTase3 is a newly identified geranylgeranyltransferase targeting a ubiquitin ligase

Shafi Kuchay, Hui Wang, Antonio Marzio, +6

Nature Structural & Molecular Biology

Systems BiologyProtein ExpressionNatural SciencesMolecular BiologyMolecular Genetics +3

CD36 maintains lipid homeostasis via selective uptake of monounsaturated fatty acids during matrix detachment and tumor progression

Alexander R. Terry, Véronique Nogueira, Hyunsoo Rho, +9

Cell Metabolism

Selective UptakeImmunologyMatrix DetachmentLipid MovementMedicine +5

Double Knockouts Reveal that Protein Tyrosine Phosphatase 1B Is a Physiological Target of Calpain-1 in Platelets

Shafi Kuchay, Nayoung Kim, Elizabeth A. Grunz, +2

Molecular and Cellular Biology

Cell DeathCytoskeletonPlatelet AggregationCellular PhysiologyClot Retraction +17