PHOTACs enable optical control of protein degradation

Martin Reynders, Bryan S. Matsuura, Marleen Bérouti, +4

Science Advances

PTEN counteracts FBXL2 to promote IP3R3- and Ca2+-mediated apoptosis limiting tumour growth

Shafi Kuchay, Carlotta Giorgi, Daniele Simoneschi, +11

Nature

Cancer ResearchTumour GrowthMedicineApoptosisCell Death +7

FBXL5 Regulates IRP2 Stability in Iron Homeostasis via an Oxygen-Responsive [2Fe2S] Cluster

Hui Wang, Hui Shi, Malini Rajan, +8

Molecular Cell

Redox SignalingPeriodic Surface StructuresSignal TransductionBiochemistryHeme Homeostasis +10

CRL4AMBRA1 is a master regulator of D-type cyclins

Daniele Simoneschi, Gergely Róna, Nan Zhou, +18

Nature

Molecular BiologyMaster RegulatorMolecular Regulation

AMBRA1 regulates cyclin D to guard S-phase entry and genomic integrity

Emiliano Maiani, Giacomo Milletti, Francesca Nazio, +43

Nature

ChromatinTranscriptional RegulationNatural SciencesGenomic IntegrityGenomic Mechanism +7

The TDH–GCN5L1–Fbxo15–KBP axis limits mitochondrial biogenesis in mouse embryonic stem cells

Valerio Donato, Massimo Bonora, Daniele Simoneschi, +8

Nature Cell Biology

Developmental BiologyMitochondrial BiogenesisMitochondrial FunctionMedicineStem Cell Research +4

The ULK1-FBXW5-SEC23B nexus controls autophagy

Yeon‐Tae Jeong, Daniele Simoneschi, Sarah Keegan, +10

eLife

Cell AutophagyMitophagySignal TransductionAutoantibody ProductionMedicine +12

Epigenetic silencing of the ubiquitin ligase subunit FBXL7 impairs c-SRC degradation and promotes epithelial-to-mesenchymal transition and metastasis

Loredana Moro, Daniele Simoneschi, Emma Kurz, +15

Nature Cell Biology

Epigenetic SilencingChromatinEpithelial-to-mesenchymal TransitionChromatin RemodelingMedicine +9

Loss of FBXO31-mediated degradation of DUSP6 dysregulates ERK and PI3K-AKT signaling and promotes prostate tumorigenesis

Shanshan Duan, Loredana Moro, Rui Qu, +8

Cell Reports

CDK-independent role of D-type cyclins in regulating DNA mismatch repair

Gergely Róna, Bearach Miwatani-Minter, Qingyue Zhang, +21

Molecular Cell

Reductive StressChromatinTranscriptional RegulationGenome InstabilityCell Regulation +13