Efficient Gene Disruption in Diverse Strains of Toxoplasma gondii Using CRISPR/CAS9

Bang Shen, Kevin M. Brown, Tobie D. Lee, +1

mBio

Say No to DMSO: Dimethylsulfoxide Inactivates Cisplatin, Carboplatin, and Other Platinum Complexes

Matthew D. Hall, Katherine A. Telma, Ki-Eun Chang, +6

Cancer Research

Discovery and Optimization of Potent, Cell-Active Pyrazole-Based Inhibitors of Lactate Dehydrogenase (LDH)

Ganesha Rai, Kyle R. Brimacombe, Bryan T. Mott, +26

Journal of Medicinal Chemistry

Dynamic Imaging of LDH Inhibition in Tumors Reveals Rapid In Vivo Metabolic Rewiring and Vulnerability to Combination Therapy

Nobu Oshima, Ryo Ishida, Shun Kishimoto, +38

Cell Reports

Dynamic ImagingEngineeringOncologic ImagingMedicineTheranostics +11

Pan-cancer proteogenomics expands the landscape of therapeutic targets

Sara R. Savage, Xinpei Yi, Jonathan T. Lei, +14

Cell

Functional Analysis of Rhomboid Proteases during <i>Toxoplasma</i> Invasion

Bang Shen, Jeffrey S. Buguliskis, Tobie D. Lee, +1

mBio

Assessing inhibitors of mutant isocitrate dehydrogenase using a suite of pre-clinical discovery assays

Daniel J. Urban, Natalia J. Martinez, Mindy I. Davis, +22

Scientific Reports

Structural Characterization of Degrader-Induced Ternary Complexes Using Hydrogen–Deuterium Exchange Mass Spectrometry and Computational Modeling: Implications for Structure-Based Design

Scott J. Eron, Hongwei Huang, Roman V. Agafonov, +10

ACS Chemical Biology

Structural CharacterizationProtein AssemblyMolecular BiologyComplex FormationChemistry +20

Pyrazole-Based Lactate Dehydrogenase Inhibitors with Optimized Cell Activity and Pharmacokinetic Properties

Ganesha Rai, Daniel J. Urban, Bryan T. Mott, +42

Journal of Medicinal Chemistry

Discovery and optimization of piperazine-1-thiourea-based human phosphoglycerate dehydrogenase inhibitors

Jason M. Rohde, Kyle R. Brimacombe, Li Liu, +12

Bioorganic & Medicinal Chemistry

BiochemistryMedicineRational Drug DesignDrug DevelopmentPharmacology +1