Dose-response curve slope sets class-specific limits on inhibitory potential of anti-HIV drugs

Lin Shen, Susan Peterson, Ahmad R. Sedaghat, +8

Nature Medicine

MedicineDose-response Curve SlopeResistance Mutation (Virology)PharmacotherapyAnti-hiv Drugs +7

Small-molecule screening using a human primary cell model of HIV latency identifies compounds that reverse latency without cellular activation

Hung‐Chih Yang, Sifei Xing, Liang Shan, +10

Journal of Clinical Investigation

EngineeringReverse LatencyImmunologyMolecular BiologyImmunotherapy +18

Molecular Characterization of Preintegration Latency in Human Immunodeficiency Virus Type 1 Infection

Theodore C. Pierson, Yan Zhou, Tara L. Kieffer, +3

Journal of Virology

Nuclear Retention of Multiply Spliced HIV-1 RNA in Resting CD4+ T Cells

Kara G. Lassen, Kasra X. Ramyar, Justin R. Bailey, +2

PLoS Pathogens

Viral ReplicationImmunologyMolecular BiologyHiv-1 LatencyTranscriptional Regulation +16

Analysis of Human Immunodeficiency Virus Type 1 Gene Expression in Latently Infected Resting CD4 ⁺ T Lymphocytes In Vivo

Monika Hermankova, Janet D. Siliciano, Yan Zhou, +5

Journal of Virology

ImmunodeficienciesImmunologyCd4 T Cell ResponsesImmune SystemImmunotherapy +18

Novel Single-Cell-Level Phenotypic Assay for Residual Drug Susceptibility and Reduced Replication Capacity of Drug-Resistant Human Immunodeficiency Virus Type 1

Haili Zhang, Yan Zhou, Cecily Alcock, +8

Journal of Virology

ImmunologyAntiviral DrugImmunotherapyDrug ResistanceHuman Retrovirus +14

In vitro and in vivo evaluation of actively targetable nanoparticles for paclitaxel delivery

Zhenghong Xu, Wangwen Gu, Jun Huang, +5

International Journal of Pharmaceutics

NanoparticlesNanomedicineEngineeringPolymer-drug ConjugateVivo Evaluation +8

Spatially resolved proteomics via tissue expansion

Lu Li, Cuiji Sun, Yaoting Sun, +12

Nature Communications

Hepatic cholesterol accumulation ascribed to the activation of ileum Fxr-Fgf15 pathway inhibiting hepatic Cyp7a1 in high-fat diet-induced obesity rats

Yingting Duan, Fan Zhang, Wenzhen Yuan, +6

Life Sciences

ObesityInflammationMetabolic SyndromeIleum Fxr-fgf15 PathwayHepatology +12

Evaluation of Apelin and Insulin Resistance in Patients with PCOS and Therapeutic Effect of Drospirenone-Ethinylestradiol Plus Metformin

Xianchang Sun, Xingguo Wu, Yan Zhou, +2

Medical Science Monitor