DRUG-seq for miniaturized high-throughput transcriptome profiling in drug discovery

Chaoyang Ye, Daniel Ho, Marilisa Neri, +14

Nature Communications

Englerin A Agonizes the TRPC4/C5 Cation Channels to Inhibit Tumor Cell Line Proliferation

Cheryl Carson, Pichai Raman, Jennifer Tullai, +29

PLoS ONE

Trpc4/c5 Cation ChannelsTrpc4 ChannelCancer BiologyCellular PhysiologyTumor Biology +14

CPSF3-dependent pre-mRNA processing as a druggable node in AML and Ewing’s sarcoma

Nathan T. Ross, Felix Lohmann, Seth Carbonneau, +39

Nature Chemical Biology

Transcriptional RegulationMedicineCancer Cell BiologyDruggable NodeCpsf3-dependent Pre-mrna Processing +7

DCAF1-based PROTACs with activity against clinically validated targets overcoming intrinsic- and acquired-degrader resistance

Martin Schröder, Martin Renatus, Xiaoyou Liang, +37

Nature Communications

Secretion of Proinflammatory Cytokines and Chemokines during Amphotericin B Exposure Is Mediated by Coactivation of Toll-Like Receptors 1 and 2

Raymund R. Razonable, Martin Hénault, Linda N. Lee, +4

Antimicrobial Agents and Chemotherapy

Innate Immune SystemImmunologyCell DeathPathologyImmunotherapy +17

Activation of human STING by a molecular glue-like compound

Jie Li, Stephen M. Canham, Hua Wu, +32

Nature Chemical Biology

The identification of 4,7-disubstituted naphthoic acid derivatives as UDP-competitive antagonists of P2Y14

Jacques Yves Gauthier, Michel Belley, Denis Deschênes, +20

Bioorganic & Medicinal Chemistry Letters

Pharmaceutical ScienceDerivative (Chemistry)BiochemistryNatural SciencesMedicine +7

Applying the pro-drug approach to afford highly bioavailable antagonists of P2Y14

Joël Robichaud, Jean‐François Fournier, Sébastien Gagné, +12

Bioorganic & Medicinal Chemistry Letters

Pharmacological StudyBiochemistryMedicinePro-drug ApproachBioavailable Antagonists +5

An IMiD-inducible degron provides reversible regulation for chimeric antigen receptor expression and activity

Seth Carbonneau, Sujata Sharma, Liaomin Peng, +13

Cell chemical biology

Reversible RegulationMolecular ImmunologySignal TransductionViral ImmunityImmunology +9

Stimulation of toll-like receptor 2 with bleomycin results in cellular activation and secretion of pro-inflammatory cytokines and chemokines

Raymund R. Razonable, Martin Hénault, C PAYA

Toxicology and Applied Pharmacology

InflammationToll-like ReceptorsCytokineAnti-inflammatoryAutoimmune Disease +12