DRUG-seq for miniaturized high-throughput transcriptome profiling in drug discovery

Chaoyang Ye, Daniel Ho, Marilisa Neri, +14

Nature Communications

YAP, but Not RSPO-LGR4/5, Signaling in Biliary Epithelial Cells Promotes a Ductular Reaction in Response to Liver Injury

Lara Planas‐Paz, Tianliang Sun, Monika Pikiolek, +36

Cell stem cell

Signal TransductionDevelopmental BiologyHepatologyLiver InjuryBiliary Epithelial Cells +12

Coarse-Grained Model of Proteins Incorporating Atomistic Detail of the Active Site

Marilisa Neri, Claudio Anselmi, Michele Cascella, +2

Physical Review Letters

Protein AssemblyBiomolecular Structure PredictionMolecular BiologyMolecular DynamicsMolecular Recognition Processes +15

CellSIUS provides sensitive and specific detection of rare cell populations from complex single-cell RNA-seq data

Rebekka Wegmann, Marilisa Neri, Sven Schuierer, +11

Genome biology

GeneticsGenomicsSingle Cell SequencingMethodology GapStem Cells +17

Single-cell and bulk transcriptomics of the liver reveals potential targets of NASH with fibrosis

Zhongyi Wang, Adrian Keogh, Annick Waldt, +16

Scientific Reports

Sustained Trem2 stabilization accelerates microglia heterogeneity and Aβ pathology in a mouse model of Alzheimer’s disease

Rahul Dhandapani, Marilisa Neri, Mario Bernhard, +17

Cell Reports

ImmunologySynaptic SignalingNeuroinflammationInflammationAlzheimer's Disease +16

Microseconds Dynamics Simulations of the Outer-Membrane Protease T

Marilisa Neri, Marc Baaden, Vincenzo Carnevale, +3

Biophysical Journal

Outer-membrane Protease TProtein FoldingMolecular BiologyMembrane SystemMedicine +3

DRUG-seq Provides Unbiased Biological Activity Readouts for Neuroscience Drug Discovery

Jingyao Li, Daniel Ho, Martin Hénault, +18

ACS Chemical Biology

Molecular dynamics simulations of outer-membrane protease T from<i>E. coli</i>based on a hybrid coarse-grained/atomistic potential

Marilisa Neri, Claudio Anselmi, Vincenzo Carnevale, +2

Journal of Physics Condensed Matter

Biophysical ModelingProtein AssemblyMolecular BiologyEscherichia ColiAnalytical Ultracentrifugation +18

Molecular characterization of chronic cutaneous wounds reveals subregion‐ and wound type‐specific differential gene expression

Shola M. Richards, Caroline Gubser Keller, Robert Kreutzer, +32

International Wound Journal