Novel Potent and Selective Bile Acid Derivatives as TGR5 Agonists: Biological Screening, Structure−Activity Relationships, and Molecular Modeling Studies

Hiroyuki Sato, Antonio Macchiarulo, Charles Thomas, +7

Journal of Medicinal Chemistry

d-3-Hydroxyacyl-CoA Dehydratase/d-3-Hydroxyacyl-CoA Dehydrogenase Bifunctional Protein Deficiency: A Newly Identified Peroxisomal Disorder

Yasuyuki Suzuki, Ling Jiang, Masayoshi Souri, +8

The American Journal of Human Genetics

Aldehyde DehydrogenaseBiochemistryPeroxisomal DisorderMetabolic DiseaseGenetics +6

Bile Salt Composition and Distribution of the D-Cysteinolic Acid Conjugated Bile Salts in Fish

Takanobu Goto, Takuji Ui, Mizuho Une, +3

Fisheries Science

Structure-activity relationship of bile acids and bile acid analogs in regard to FXR activation

Tomofumi Fujino, Mizuho Une, Tsuneo Imanaka, +2

Journal of Lipid Research

OxysterolBiochemistryBiliary TractNatural SciencesLiver Physiology +5

Identification of intermediates in the bile acid synthetic pathway as ligands for the farnesoid X receptor

Tomoko Nishimaki‐Mogami, Mizuho Une, Tomofumi Fujino, +5

Journal of Lipid Research

Occurrence of bile alcohol glucuronides in bile of patients with cerebrotendinous xanthomatosis

Takahiko Hoshita, M Yasuhara, Mizuho Une, +4

Journal of Lipid Research

Identification of unconjugated bile acids in human bile.

N Matoba, Mizuho Une, T Hoshita

Journal of Lipid Research

Prevention of cholesterol-induced gallstones by hyodeoxycholic acid in the prairie dog.

Anil Singhal, Bertram I. Cohen, E.H. Mosbach, +5

Journal of Lipid Research

Effects of Chemical Modification of Ursodeoxycholic Acid on TGR5 Activation

Yusuke Iguchi, Tomoko Nishimaki‐Mogami, Masafumi Yamaguchi, +3

Biological and Pharmaceutical Bulletin

Molecular PharmacologyOxysterolBiochemistryTgr5 ActivationBile Acid Analogues +7

Unique Inhibition of Bile Salt-Induced Apoptosis by Lecithins and Cytoprotective Bile Salts in Immortalized Mouse Cholangiocytes

Daisuke Komichi, Susumu Tazuma, Tomoji Nishioka, +3

Digestive Diseases and Sciences

Unique InhibitionBiliary TractMedicineLiver PhysiologyApoptosis +9