The clonal and mutational evolution spectrum of primary triple-negative breast cancers

Sohrab P. Shah, Andrew Roth, Rodrigo Goya, +56

Nature

Breast OncologyTumor HeterogeneityMedicinePathologyCancer Genomics +8

Dynamics of genomic clones in breast cancer patient xenografts at single-cell resolution

Peter Eirew, Adi Steif, Jaswinder Khattra, +43

Nature

XenotransplantationSomatic VariantTumor HeterogeneitySingle-cell ResolutionMedicine +10

Distinct evolutionary trajectories of primary high‐grade serous ovarian cancers revealed through spatial mutational profiling

Ali Bashashati, Gavin Ha, Alicia Tone, +22

The Journal of Pathology

TITAN: inference of copy number architectures in clonal cell populations from tumor whole-genome sequence data

Gavin Ha, Andrew Roth, Jaswinder Khattra, +18

Genome Research

Clonal Cell PopulationsEngineeringCopy Number ArchitecturesGeneticsGenomics +17

Double-Hit Gene Expression Signature Defines a Distinct Subgroup of Germinal Center B-Cell-Like Diffuse Large B-Cell Lymphoma

Daisuke Ennishi, Aixiang Jiang, Merrill Boyle, +27

Journal of Clinical Oncology

Interfaces of Malignant and Immunologic Clonal Dynamics in Ovarian Cancer

Allen W. Zhang, Andrew McPherson, Katy Milne, +42

Cell

Malignant DiseaseTumor HeterogeneityMedicineGynecologyRadiation Oncology +7

Divergent modes of clonal spread and intraperitoneal mixing in high-grade serous ovarian cancer

Andrew McPherson, Andrew Roth, Emma Laks, +31

Nature Genetics

Surgical OncologyTumoral PathologyMedicineClonal SpreadDivergent Modes +7

DriverNet: uncovering the impact of somatic driver mutations on transcriptional networks in cancer

Ali Bashashati, Gholamreza Haffari, Jiarui Ding, +7

Genome biology

Molecular and Genetic Characterization of MHC Deficiency Identifies EZH2 as Therapeutic Target for Enhancing Immune Recognition

Daisuke Ennishi, Katsuyoshi Takata, Wendy Béguelin, +23

Cancer Discovery

Integrative analysis of genome-wide loss of heterozygosity and monoallelic expression at nucleotide resolution reveals disrupted pathways in triple-negative breast cancer

Gavin Ha, Andrew Roth, Daniel Lai, +14

Genome Research

Breast OncologyGeneticsTranscriptomics TechnologyIntegrative AnalysisTumor Biology +14