Sweta Iyer

Bax targets mitochondria by distinct mechanisms before or during apoptotic cell death: a requirement for VDAC2 or Bak for efficient Bax apoptotic function

Thanh Ngoc Nguyen, Iris K. L. Tan, Robert L. Ninnis et al. · Cell Death and Differentiation · 2014 · 128 citations · Full text

Distinct Mechanisms, Mitophagy, Mitochondrial Function +11

Apoptotic pore formation is associated with in-plane insertion of Bak or Bax central helices into the mitochondrial outer membrane

Dana Westphal, Grant Dewson, Marie Ménard et al. · Proceedings of the National Academy of Sciences · 2014 · 122 citations · Full text

Molecular Biology, Cell Death, Bax Central Helices +21

Disordered clusters of Bak dimers rupture mitochondria during apoptosis

Rachel T. Uren, Martin O’Hely, Sweta Iyer et al. · eLife · 2017 · 97 citations · Full text

Proteinlipid Interaction, Apoptosis, Molecular Biology +16

Bak apoptotic pores involve a flexible C-terminal region and juxtaposition of the C-terminal transmembrane domains

Sweta Iyer, F. Bell, Dana Westphal et al. · Cell Death and Differentiation · 2015 · 62 citations · Full text

Signal Transduction, Biochemistry, Flexible C-terminal Region +12

Epigenetic control of mitochondrial cell death through PACS1-mediated regulation of BAX/BAK oligomerization

Daniella Brasacchio, Amber E. Alsop, Tahereh Noori et al. · Cell Death and Differentiation · 2017 · 60 citations · Full text

Bax/bak Oligomerization, Mitophagy, Signal Transduction +10