H.L. Silvestre

Application of Fragment Growing and Fragment Linking to the Discovery of Inhibitors of <i>Mycobacterium tuberculosis</i> Pantothenate Synthetase

Alvin W. Hung, H.L. Silvestre, Shijun Wen et al. · Angewandte Chemie International Edition · 2009 · 144 citations

Application of Fragment Growing and Fragment Linking to the Discovery of Inhibitors of <i>Mycobacterium tuberculosis</i> Pantothenate Synthetase

Alvin W. Hung, H.L. Silvestre, Shijun Wen et al. · Angewandte Chemie · 2009 · 115 citations

Antiparasitic Agent, Pharmacotherapy, Systematisch Zu Verbessern +20

Integrated biophysical approach to fragment screening and validation for fragment-based lead discovery

H.L. Silvestre, T.L. Blundell, Chris Abell et al. · Proceedings of the National Academy of Sciences · 2013 · 106 citations · Full text

X-ray Crystallography, Hit Identification, Biomolecular Structure Prediction +23

Optimization of the Interligand Overhauser Effect for Fragment Linking: Application to Inhibitor Discovery against <i>Mycobacterium tuberculosis</i> Pantothenate Synthetase

P. Sledz, H.L. Silvestre, Alvin W. Hung et al. · Journal of the American Chemical Society · 2010 · 75 citations · Full text

Protein Assembly, Biomolecular Structure Prediction, Molecular Biology +18

Scaffold-Hopping Approach To Discover Potent, Selective, and Efficacious Inhibitors of NF-κB Inducing Kinase

Nicole Blaquière, Georgette M. Castanedo, Jason D. Burch et al. · Journal of Medicinal Chemistry · 2018 · 51 citations · Full text

Lead Compounds, Drug Target, Lead Identification +24