Study of the Individual Contributions of Ice Formation and Freeze-Concentration on Isothermal Stability of Lactate Dehydrogenase during Freezing

Bakul Bhatnagar, Michael J. Pikal, Robin H. Bogner

Journal of Pharmaceutical Sciences

EngineeringIsothermal StabilityBiochemistryBioenergeticsLactate Dehydrogenase +6

Drying technologies for biopharmaceutical applications: Recent developments and future direction

Alex Langford, Bakul Bhatnagar, Robert H. Walters, +2

Drying Technology

BiomanufacturingEngineeringDesiccationEdible PackagingNext-generation Drying Technologies +9

Bulk Dynamic Spray Freeze-Drying Part 1: Modeling of Droplet Cooling and Phase Change

Israel B. Sebastião, Bakul Bhatnagar, Serguei Tchessalov, +4

Journal of Pharmaceutical Sciences

Freeze-thaw CyclingEngineeringDesiccationFluid MechanicsMechanical Engineering +9

Reliable determination of freeze-concentration using DSC

Bakul Bhatnagar, Stéphane Cardon, Michael J. Pikal, +1

Thermochimica Acta

Freeze-thaw CyclingEngineeringAtmospheric IcingMeasurementCalibration +4

Protein/Ice Interaction: High-Resolution Synchrotron X-ray Diffraction Differentiates Pharmaceutical Proteins from Lysozyme

Bakul Bhatnagar, B.A. Zakharov, Alexander S. Fisyuk, +8

The Journal of Physical Chemistry B

X-ray CrystallographyProtein ChemistryIce CrystalsProtein/ice InteractionBiochemistry +12

Practical Advice on Scientific Design of Freeze-Drying Process: 2023 Update

Serguei Tchessalov, Vito Maglio, Petr Kazarin, +4

Pharmaceutical Research

Bulk Dynamic Spray Freeze-Drying Part 2: Model-Based Parametric Study for Spray-Freezing Process Characterization

Israel B. Sebastião, Bakul Bhatnagar, Serguei Tchessalov, +4

Journal of Pharmaceutical Sciences

Thermal Spray CoatingFreeze-thaw CyclingEngineeringDesiccationMechanical Engineering +7

Best Practices and Guidelines (2022) for Scale-Up and Tech Transfer in Freeze-Drying Based on Case Studies. Part 1: Challenges during Scale Up and Transfer

Serguei Tchessalov, Evgenyi Shalaev, Bakul Bhatnagar, +18

AAPS PharmSciTech

EngineeringFreeze-drying Process Scale-upMechanical EngineeringRefrigerationDesiccation +14

A refined phase diagram of the <i>tert</i>-butanol–water system and implications on lyophilization process optimization of pharmaceuticals

Bakul Bhatnagar, Jayesh Sonje, Evgenyi Shalaev, +3

Physical Chemistry Chemical Physics

Lyophilization Process OptimizationEngineeringChemistrySolution (Chemistry)Chemical Engineering +17

Investigation of PEG Crystallization in Frozen PEG–Sucrose–Water Solutions: II. Characterization of the Equilibrium Behavior During Freeze-Thawing

Bakul Bhatnagar, Susan M. Martin, Dirk L. Teagarden, +2

Journal of Pharmaceutical Sciences

Frozen Peg–sucrose–water SolutionsChemistryEquilibrium BehaviorBiophysicsSolution (Chemistry) +1