PF-04691502, a Potent and Selective Oral Inhibitor of PI3K and mTOR Kinases with Antitumor Activity

Jing Yuan, Pramod P. Mehta, Min-Jean Yin, +18

Molecular Cancer Therapeutics

Antitumor ActivityPten LossCancer BiologyTumor BiologySignaling Pathway +20

Metabolism, excretion and pharmacokinetics of [¹⁴C]crizotinib following oral administration to healthy subjects

Theodore R. Johnson, Weiwei Tan, Lance Goulet, +12

Xenobiotica

Tumor P-Glycoprotein Correlates with Efficacy of PF-3758309 in in vitro and in vivo Models of Colorectal Cancer

Erica L. Bradshaw‐Pierce, Todd M. Pitts, Aik Choon Tan, +9

Frontiers in Pharmacology

Tumor XenograftsChemoprevention StrategyTumor P-gpPathologyCancer Biology +14

Discovery Pharmacokinetic Studies in Mice Using Serial Microsampling, Dried Blood Spots And Microbore Lc–MS/MS

Sadayappan V. Rahavendran, Sylvia Vekich, Heather Skor, +4

Bioanalysis

High-throughput preparative process utilizing three complementary chromatographic purification technologies

Manuel Ventura, William Farrell, Christine M. Aurigemma, +11

Journal of Chromatography A

Chemical EngineeringEngineeringDownstream ProcessingAnalytical ChemistryHigh-throughput Preparative Process +3

Quantitative analysis of PD 0332991 in xenograft mouse tumor tissue by a 96-well supported liquid extraction format and liquid chromatography/mass spectrometry

Leslie Nguyen, Wei-Zhu Zhong, Cory L. Painter, +3

Journal of Pharmaceutical and Biomedical Analysis

EngineeringBioanalysisQuantitative AnalysisMass SpectrometryPathology +8

Comparison of the ex vivo receptor occupancy profile of ketamine to several NMDA receptor antagonists in mouse hippocampus

Brian Lord, Cindy Wintmolders, Xavier Langlois, +3

European Journal of Pharmacology

NeurophysiologyMedicineNeurotransmitterNeuropharmacologyExperimental Pharmacology +6

Pharmacokinetic-Pharmacodynamic Modeling of Biomarker Response and Tumor Growth Inhibition to an Orally Available Heat Shock Protein 90 Inhibitor in a Human Tumor Xenograft Mouse Model

Shinji Yamazaki, Leslie Nguyen, Sylvia Vekich, +5

Journal of Pharmacology and Experimental Therapeutics

Pharmacologic Characterization of JNJ-42226314, [1-(4-Fluorophenyl)indol-5-yl]-[3-[4-(thiazole-2-carbonyl)piperazin-1-yl]azetidin-1-yl]methanone, a Reversible, Selective, and Potent Monoacylglycerol Lipase Inhibitor

Ryan M. Wyatt, Ian Fraser, Natalie Welty, +24

Journal of Pharmacology and Experimental Therapeutics

Novel Phenyl-Substituted 5,6-Dihydro-[1,2,4]triazolo[4,3-<i>a</i>]pyrazine P2X7 Antagonists with Robust Target Engagement in Rat Brain

Christa C. Chrovian, Akinola Soyode-Johnson, Hong Ao, +8

ACS Chemical Neuroscience

Robust Target EngagementMolecular PharmacologyMedicinal ChemistryPharmacological StudyMedicine +13