Discovery Pharmacokinetic Studies in Mice Using Serial Microsampling, Dried Blood Spots And Microbore Lc–MS/MS

Abstract

Serial blood microsampling has led to reduced animal and compound usage with improved PK data. Ex vivo BPR is suitable in a discovery setting. Microbore LC-MS/MS is well suited in instances where sample volume is limited, and enables faster analyses, reduced solvent use, and less frequent MS source cleaning.