Short Term Exercise Induces PGC-1α, Ameliorates Inflammation and Increases Mitochondrial Membrane Proteins but Fails to Increase Respiratory Enzymes in Aging Diabetic Hearts

Amy Botta, Ismail Laher, Julianne Beam, +6

PLoS ONE

Cardiometabolic RiskMetabolic RemodelingCardiovascular FunctionInsulin SignalingOxidative Stress +21

Excess Linoleic Acid Increases Collagen I/III Ratio and “Stiffens” the Heart Muscle Following High Fat Diets

Julianne Beam, Amy Botta, Jiayu Ye, +5

Journal of Biological Chemistry

Holo-lipocalin-2–derived siderophores increase mitochondrial ROS and impair oxidative phosphorylation in rat cardiomyocytes

Erfei Song, Sofhia V. Ramos, Xiaojing Huang, +10

Proceedings of the National Academy of Sciences

A high-fat diet rich in corn oil reduces spontaneous locomotor activity and induces insulin resistance in mice

Chi Kin Wong, Amy Botta, Jason Pither, +3

The Journal of Nutritional Biochemistry

ObesityNutritionMetabolic SyndromeEnergy HomeostasisLipid Nutrition +9

An adiponectin-S1P axis protects against lipid induced insulin resistance and cardiomyocyte cell death via reduction of oxidative stress

Amy Botta, Ying Liu, Sivaporn Wannaiampikul, +4

Nutrition & Metabolism

Glutathione administration reduces mitochondrial damage and shifts cell death from necrosis to apoptosis in ageing diabetic mice hearts during exercise

Saeid Golbidi, Amy Botta, S Gottfred, +3

British Journal of Pharmacology

An adiponectin-S1P autocrine axis protects skeletal muscle cells from palmitate-induced cell death

Amy Botta, Kazaros Elizbaryan, Parastoo Tashakorinia, +2

Lipids in Health and Disease

Short-term exercise worsens cardiac oxidative stress and fibrosis in 8-month-old<i>db/db</i>mice by depleting cardiac glutathione

Ismail Laher, Julianne Beam, Amy Botta, +5

Free Radical Research

Aerobic ExerciseShort-term ExerciseCardiovascular FunctionCardiovascular ToxicityOxidative Stress +19

Egg white consumption increases GSH and lowers oxidative damage in 110-week-old geriatric mice hearts

Jiayu Ye, Amy Botta, Svetlana Simtchouk, +6

The Journal of Nutritional Biochemistry

NutritionAgingLongevityLipid PeroxidationPhysiology +5

A Unique Conformational Distortion Mechanism Drives Lipocalin 2 Binding to Bacterial Siderophores

Xiaojing Huang, Sladjana Slavkovic, Erfei Song, +6

ACS Chemical Biology

Proteinlipid InteractionProtein AssemblyMolecular BiologyLipid MovementType Ii +15