Simone C. Oostindie

A Novel Platform for the Potentiation of Therapeutic Antibodies Based on Antigen-Dependent Formation of IgG Hexamers at the Cell Surface

Rob N. de Jong, Frank J. Beurskens, Sandra Verploegen et al. · PLoS Biology · 2016 · 218 citations · Full text

DuoBody-CD3xCD20 induces potent T-cell-mediated killing of malignant B cells in preclinical models and provides opportunities for subcutaneous dosing

Patrick Engelberts, Ida H. Hiemstra, Bart de Jong et al. · EBioMedicine · 2020 · 159 citations · Full text

DuoHexaBody-CD37®, a novel biparatopic CD37 antibody with enhanced Fc-mediated hexamerization as a potential therapy for B-cell malignancies

Simone C. Oostindie, Hilma J. van der Horst, Laurens P. Kil et al. · Blood Cancer Journal · 2020 · 68 citations · Full text

CD20 and CD37 antibodies synergize to activate complement by Fc-mediated clustering

Simone C. Oostindie, Hilma J. van der Horst, Margaret A. Lindorfer et al. · Haematologica · 2019 · 61 citations · Full text

Antibodies That Efficiently Form Hexamers upon Antigen Binding Can Induce Complement-Dependent Cytotoxicity under Complement-Limiting Conditions

Erika M. Cook, Margaret A. Lindorfer, Hilma van der Horst et al. · The Journal of Immunology · 2016 · 58 citations · Full text