Laurens P. Kil

Btk levels set the threshold for B-cell activation and negative selection of autoreactive B cells in mice

Laurens P. Kil, Marjolein J. W. de Bruijn, Menno van Nimwegen et al. · Blood · 2012 · 203 citations · Full text

Life Sciences, Cell Biology, Immunology +15

DuoHexaBody-CD37®, a novel biparatopic CD37 antibody with enhanced Fc-mediated hexamerization as a potential therapy for B-cell malignancies

Simone C. Oostindie, Hilma J. van der Horst, Laurens P. Kil et al. · Blood Cancer Journal · 2020 · 70 citations · Full text

Pharmacy, Immunology, Oncology +17

Bruton's tyrosine kinase mediated signaling enhances leukemogenesis in a mouse model for chronic lymphocytic leukemia.

Laurens P. Kil, Marjolein Jw de Bruijn, Jennifer Ac van Hulst et al. · PubMed · 2013 · 58 citations

Life Sciences, Hematology, Oncology +16

Enhanced Expression of Bruton’s Tyrosine Kinase in B Cells Drives Systemic Autoimmunity by Disrupting T Cell Homeostasis

Odilia B. J. Corneth, Marjolein J. W. de Bruijn, Jasper Rip et al. · The Journal of Immunology · 2016 · 51 citations

Life Sciences, Immunology, Pathology +17

Constitutive activation of Bruton's tyrosine kinase induces the formation of autoreactive IgM plasma cells

Rogier Kersseboom, Laurens P. Kil, Roelof Flierman et al. · European Journal of Immunology · 2010 · 30 citations

Life Sciences, Immunology, Molecular Biology +17