Patrick Engelberts

A Novel Platform for the Potentiation of Therapeutic Antibodies Based on Antigen-Dependent Formation of IgG Hexamers at the Cell Surface

Rob N. de Jong, Frank J. Beurskens, Sandra Verploegen et al. · PLoS Biology · 2016 · 226 citations · Full text

Pharmacy, Immunology, Oncology +17

DuoBody-CD3xCD20 induces potent T-cell-mediated killing of malignant B cells in preclinical models and provides opportunities for subcutaneous dosing

Patrick Engelberts, Ida H. Hiemstra, Bart de Jong et al. · EBioMedicine · 2020 · 168 citations · Full text

Life Sciences, Immunology, Oncology +15

Ibrutinib interferes with the cell-mediated anti-tumor activities of therapeutic CD20 antibodies: implications for combination therapy

Fabio Da Roit, Patrick Engelberts, Ronald P. Taylor et al. · Haematologica · 2014 · 145 citations · Full text

Medicine, Pharmacology, Pharmacotherapy +17

Loss of CD20 and Bound CD20 Antibody from Opsonized B Cells Occurs More Rapidly Because of Trogocytosis Mediated by Fc Receptor-Expressing Effector Cells Than Direct Internalization by the B Cells

Paul V. Beum, Elizabeth M. Peek, Margaret A. Lindorfer et al. · The Journal of Immunology · 2011 · 139 citations · Full text

Life Sciences, Cell Biology, Immunology +16

Statins Impair Antitumor Effects of Rituximab by Inducing Conformational Changes of CD20

Magdalena Winiarska, Jacek Bil, Ewa Wilczek et al. · PLoS Medicine · 2008 · 122 citations · Full text

Medicine, Immunology, Pharmacology +17