Rituximab Infusion Promotes Rapid Complement Depletion and Acute CD20 Loss in Chronic Lymphocytic Leukemia

Adam D. Kennedy, Paul V. Beum, Michael D. Solga, +6

The Journal of Immunology

Binding of Submaximal C1q Promotes Complement-Dependent Cytotoxicity (CDC) of B Cells Opsonized with Anti-CD20 mAbs Ofatumumab (OFA) or Rituximab (RTX): Considerably Higher Levels of CDC Are Induced by OFA than by RTX

Andrew W. Pawluczkowycz, Frank J. Beurskens, Paul V. Beum, +4

The Journal of Immunology

Clinical ImmunologyCdc Are InducedImmunologyCell DeathImmunologic Mechanism +16

The Shaving Reaction: Rituximab/CD20 Complexes Are Removed from Mantle Cell Lymphoma and Chronic Lymphocytic Leukemia Cells by THP-1 Monocytes

Paul V. Beum, Adam D. Kennedy, Michael E. Williams, +2

The Journal of Immunology

Thrice-Weekly Low-Dose Rituximab Decreases CD20 Loss via Shaving and Promotes Enhanced Targeting in Chronic Lymphocytic Leukemia

Michael E. Williams, John Densmore, Andrew W. Pawluczkowycz, +6

The Journal of Immunology

Chronic Lymphocytic LeukemiaImmunologyImmunotherapyHematological MalignancyOncology +15

Loss of CD20 and Bound CD20 Antibody from Opsonized B Cells Occurs More Rapidly Because of Trogocytosis Mediated by Fc Receptor-Expressing Effector Cells Than Direct Internalization by the B Cells

Paul V. Beum, Elizabeth M. Peek, Margaret A. Lindorfer, +5

The Journal of Immunology

Humoral ResponseImmunologyImmunoeditingPathologyImmunologic Mechanism +24

Complement Activation on B Lymphocytes Opsonized with Rituximab or Ofatumumab Produces Substantial Changes in Membrane Structure Preceding Cell Lysis

Paul V. Beum, Margaret A. Lindorfer, Frank J. Beurskens, +6

The Journal of Immunology

Exhaustion of Cytotoxic Effector Systems May Limit Monoclonal Antibody-Based Immunotherapy in Cancer Patients

Frank J. Beurskens, Margaret A. Lindorfer, Mohammed Farooqui, +6

The Journal of Immunology

ImmunologyImmunoeditingCll B CellsCancer PatientsImmune Cell Therapy +20

Within Peripheral Blood Mononuclear Cells, Antibody-Dependent Cellular Cytotoxicity of Rituximab-Opsonized Daudi cells Is Promoted by NK Cells and Inhibited by Monocytes due to Shaving

Paul V. Beum, Margaret A. Lindorfer, Ronald P. Taylor

The Journal of Immunology

Binding of Rituximab, Trastuzumab, Cetuximab, or mAb T101 to Cancer Cells Promotes Trogocytosis Mediated by THP-1 Cells and Monocytes

Paul V. Beum, David A. Mack, Andrew W. Pawluczkowycz, +2

The Journal of Immunology

Quantitative analysis of protein co-localization on B cells opsonized with rituximab and complement using the ImageStream multispectral imaging flow cytometer

Paul V. Beum, Margaret A. Lindorfer, Brian E. Hall, +4

Journal of Immunological Methods

Immunocytochemical TechniqueMedicineImmunologyQuantitative AnalysisB Cells +8