Hilary Lewis

Resolution of NASH and hepatic fibrosis by the GLP-1R and GCGR dual-agonist cotadutide via modulating mitochondrial function and lipogenesis

Michelle L. Boland, Rhianna C. Laker, KARLY M. MATHER et al. · Nature Metabolism · 2020 · 255 citations · Full text

Life Sciences, Cell Biology, Pharmacology +16

Vigabatrin with hormonal treatment versus hormonal treatment alone (ICISS) for infantile spasms: 18-month outcomes of an open-label, randomised controlled trial

Finbar O’Callaghan, Stuart W. Edwards, Fabienne Dietrich Alber et al. · The Lancet Child & Adolescent Health · 2018 · 165 citations · Full text

Medicine, Neurology, Pharmacotherapy +7

Vitamin D receptor–retinoid X receptor heterodimer signaling regulates oligodendrocyte progenitor cell differentiation

Alerie Guzman de la Fuente, Oihana Errea, Peter van Wijngaarden et al. · The Journal of Cell Biology · 2015 · 150 citations · Full text

Life Sciences, Neuroscience, Pharmacology +17

Structure-Based Design of Potent and Selective Inhibitors of the Metabolic Kinase PFKFB3

Scott Boyd, Joanna Brookfield, Susan E. Critchlow et al. · Journal of Medicinal Chemistry · 2015 · 96 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +15

Structure-Based Design and Pharmacokinetic Optimization of Covalent Allosteric Inhibitors of the Mutant GTPase KRAS^G12C

Jason G. Kettle, Sharan K. Bagal, Sue Bickerton et al. · Journal of Medicinal Chemistry · 2020 · 85 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17