Henry H. Gu

Imidazoquinoxaline Src-Family Kinase p56^Lck Inhibitors:  SAR, QSAR, and the Discovery of (<i>S</i>)-<i>N</i>-(2-Chloro-6-methylphenyl)-2-(3-methyl-1-piperazinyl)imidazo- [1,5-<i>a</i>]pyrido[3,2-<i>e</i>]pyrazin-6-amine (BMS-279700) as a Potent and Orally Active Inhibitor with Excellent in Vivo Antiinflammatory Activity

Ping Chen, Arthur M. Doweyko, Derek Norris et al. · Journal of Medicinal Chemistry · 2004 · 55 citations · Full text

Immunology, Pharmacotherapy, Heterocycle Chemistry +20

Acridone-Based Inhibitors of Inosine 5‘-Monophosphate Dehydrogenase:  Discovery and SAR Leading to the Identification of <i>N</i>-(2-(6-(4-Ethylpiperazin-1-yl)pyridin-3-yl)propan-2-yl)-2- fluoro-9-oxo-9,10-dihydroacridine-3-carboxamide (BMS-566419)

Scott H. Watterson, Ping Chen, Yufen Zhao et al. · Journal of Medicinal Chemistry · 2007 · 49 citations · Full text

Sar Leading, Pharmaceutical Science, Inosine 5 +17

Discovery of <i>N</i>-[2-[2-[[3-Methoxy-4-(5-oxazolyl)phenyl]amino]-5-oxazolyl]phenyl]-<i>N</i>-methyl-4- morpholineacetamide as a Novel and Potent Inhibitor of Inosine Monophosphate Dehydrogenase with Excellent in Vivo Activity

T. G. Murali Dhar, Zhongqi Shen, Junqing Guo et al. · Journal of Medicinal Chemistry · 2002 · 41 citations · Full text

Potent Inhibitor, Pharmacotherapy, Chemical Biology +17

Rapid synthesis of triazine inhibitors of inosine monophosphate dehydrogenase

William J. Pitts, Junqing Guo, T. G. Murali Dhar et al. · Bioorganic & Medicinal Chemistry Letters · 2002 · 40 citations · Full text

Pharmacology, Triazine Inhibitors, Biochemistry +1

Discovery and initial SAR of imidazoquinoxalines as inhibitors of the Src-family kinase p56Lck

Ping Chen, Derek Norris, Edwin J. Iwanowicz et al. · Bioorganic & Medicinal Chemistry Letters · 2002 · 37 citations · Full text

Medicinal Chemistry, Bioorganic Chemistry, Biochemistry +10