Olaf Brouwers

Overexpression of Glyoxalase-I Reduces Hyperglycemia-induced Levels of Advanced Glycation End Products and Oxidative Stress in Diabetic Rats

Olaf Brouwers, Petra Niessen, Isabel Ferreira et al. · Journal of Biological Chemistry · 2010 · 227 citations · Full text

Life Sciences, Biochemistry, Endocrinology +15

Hyperglycaemia-induced impairment of endothelium-dependent vasorelaxation in rat mesenteric arteries is mediated by intracellular methylglyoxal levels in a pathway dependent on oxidative stress

Olaf Brouwers, Petra Niessen, Guido R.M.M. Haenen et al. · Diabetologia · 2010 · 191 citations · Full text

Life Sciences, Biochemistry, Physiology +14

Protection against methylglyoxal-derived AGEs by regulation of glyoxalase 1 prevents retinal neuroglial and vasodegenerative pathology

Andre Berner, Olaf Brouwers, R. Pringle et al. · Diabetologia · 2011 · 151 citations · Full text

Life Sciences, Neuroscience, Ophthalmology +16

Glyoxalase-1 overexpression reduces endothelial dysfunction and attenuates early renal impairment in a rat model of diabetes

Olaf Brouwers, Petra Niessen, Toshio Miyata et al. · Diabetologia · 2013 · 138 citations · Full text

Medicine, Nephrology, Physiology +14

Delayed Intervention With Pyridoxamine Improves Metabolic Function and Prevents Adipose Tissue Inflammation and Insulin Resistance in High-Fat Diet–Induced Obese Mice

Dionne E. Maessen, Olaf Brouwers, Katrien H.J. Gaens et al. · Diabetes · 2015 · 74 citations · Full text

Life Sciences, Biochemistry, Pharmacology +17