Overexpression of Glyoxalase-I Reduces Hyperglycemia-induced Levels of Advanced Glycation End Products and Oxidative Stress in Diabetic Rats

Olaf Brouwers, Petra Niessen, Isabel Ferreira, +7

Journal of Biological Chemistry

Hyperglycaemia-induced impairment of endothelium-dependent vasorelaxation in rat mesenteric arteries is mediated by intracellular methylglyoxal levels in a pathway dependent on oxidative stress

Olaf Brouwers, Petra Niessen, Guido R.M.M. Haenen, +5

Diabetologia

Protection against methylglyoxal-derived AGEs by regulation of glyoxalase 1 prevents retinal neuroglial and vasodegenerative pathology

Andre Berner, Olaf Brouwers, R. Pringle, +10

Diabetologia

Alzheimer's DiseaseAgingOphthalmologyGlyoxalase 1Degenerative Pathology +9

Glyoxalase-1 overexpression reduces endothelial dysfunction and attenuates early renal impairment in a rat model of diabetes

Olaf Brouwers, Petra Niessen, Toshio Miyata, +10

Diabetologia

Metabolic SyndromeMedicinePhysiologyDiabetesChronic Kidney Disease +11

Delayed Intervention With Pyridoxamine Improves Metabolic Function and Prevents Adipose Tissue Inflammation and Insulin Resistance in High-Fat Diet–Induced Obese Mice

Dionne E. Maessen, Olaf Brouwers, Katrien H.J. Gaens, +6

Diabetes

Hypertension Is a Conditional Factor for the Development of Cardiac Hypertrophy in Type 2 Diabetic Mice

Marc van Bilsen, Anneleen Daniels, Olaf Brouwers, +7

PLoS ONE

Mild Oxidative Damage in the Diabetic Rat Heart Is Attenuated by Glyoxalase-1 Overexpression

Olaf Brouwers, Joyce M J de Vos-Houben, Petra Niessen, +6

International Journal of Molecular Sciences

Redox SignalingMetabolic SyndromeHeart FailureGlyoxalase-1 OverexpressionBiochemistry +13

Polymorphisms in glyoxalase 1 gene are not associated with vascular complications: the Hoorn and CoDAM studies

Lian Engelen, Isabel Ferreira, Olaf Brouwers, +10

Journal of Hypertension

Glyoxalase 1 overexpression does not affect atherosclerotic lesion size and severity in ApoE−/− mice with or without diabetes

Nordin M.J. Hanssen, Olaf Brouwers, Marion J. Gijbels, +8

Cardiovascular Research

<i>Methylglyoxal and Methylglyoxal‐arginine Adducts Do Not Directly Inhibit Endothelial Nitric Oxide Synthase</i>

Olaf Brouwers, Tom Teerlink, Jan van Bezu, +3

Annals of the New York Academy of Sciences