The SUMO modification pathway is involved in the BRCA1 response to genotoxic stress

Joanna R. Morris, Chris Boutell, Ruth M. Densham, +8

Nature

Reductive StressGenome InstabilityDisease MechanismGeneticsGenomic Mechanism +8

The proteasomal de‐ubiquitinating enzyme POH1 promotes the double‐strand DNA break response

Laura Butler, Ruth M. Densham, Junying Jia, +7

The EMBO Journal

The ubiquitin-dependent ATPase p97 removes cytotoxic trapped PARP1 from chromatin

Dragomir B. Krastev, Shudong Li, Yilun Sun, +16

Nature Cell Biology

The deSUMOylase SENP7 promotes chromatin relaxation for homologous recombination DNA repair

Alexander J. Garvin, Ruth M. Densham, Sarah Blair-Reid, +5

EMBO Reports

ChromatinGenome InstabilityChromatin StructureChromatin RemodelingNatural Sciences +8

Genomic Complexity Profiling Reveals That HORMAD1 Overexpression Contributes to Homologous Recombination Deficiency in Triple-Negative Breast Cancers

Johnathan Watkins, Daniel Weekes, Vandna Shah, +19

Cancer Discovery

The Forkhead Box M1 protein regulates BRIP1 expression and DNA damage repair in epirubicin treatment

Lara J. Monteiro, Pasarat Khongkow, Mesayamas Kongsema, +12

Oncogene

Genome InstabilityBrip1 ExpressionDna Damage RepairMolecular BiologyMolecular Research +3

Regulation of osteosarcoma cell lung metastasis by the c-Fos/AP-1 target FGFR1

Daniel Weekes, T G Kashima, Carolina Zandueta, +10

Oncogene

Tumor BiologyMedicineC-fos/ap-1 Target Fgfr1PathologyCancer Biology +4

Integrated genomics and functional validation identifies malignant cell specific dependencies in triple negative breast cancer

Nirmesh Patel, Daniel Weekes, Patrycja Gazińska, +17

Nature Communications

Selective Ablation of Retinoblastoma Protein Function by the RET Finger Protein

Maja Krützfeldt, Mark Ellis, Daniel Weekes, +5

Molecular Cell

Selective AblationMedicineMolecular BiologyRet Finger ProteinRetinoblastoma Protein Function +2

Attenuation of disease phenotype through alternative translation initiation in low-penetrance retinoblastoma

Francisco Sánchez‐Sánchez, Carmen Ramírez‐Castillejo, Daniel Weekes, +4

Human Mutation

EngineeringLow-penetrance RetinoblastomaGeneticsPathologyTranslational Advance +16