Chemoprevention of azoxymethane-induced colonic carcinogenesis by supplemental dietary ursodeoxycholic acid.

D L Earnest, Hana Holubec, Ramesh K. Wali, +6

PubMed

NutritionChemoprevention StrategyMedicineAzoxymethane-induced Colonic CarcinogenesisGastroenterology +13

Mechanism of action of chemoprotective ursodeoxycholate in the azoxymethane model of rat colonic carcinogenesis: potential roles of protein kinase C-alpha, -beta II, and -zeta.

Ramesh K. Wali, Brendan P. Frawley, S. Hartmann, +7

PubMed

Azoxymethane ModelOncologyProtein Kinase CChemoprevention StrategyOncogenic Agent +13

Ursodeoxycholic acid and F(6)-D(3) inhibit aberrant crypt proliferation in the rat azoxymethane model of colon cancer: roles of cyclin D1 and E-cadherin.

Ramesh K. Wali, Sharad Khare, Maria Tretiakova, +10

PubMed

Acf DevelopmentOncologyChemoprevention StrategyCyclin D1Medicine +12

1 alpha,25-Dihydroxy-16-ene-23-yne-26,27-hexafluorocholecalciferol, a noncalcemic analogue of 1 alpha,25-dihydroxyvitamin D3, inhibits azoxymethane-induced colonic tumorigenesis.

Ramesh K. Wali, Marc Bissonnette, Sharad Khare, +3

PubMed

Alpha,25-dihydroxyvitamin D3Medicinal ChemistrySerum CalciumChemoprevention StrategyVitamin D3 +13

Mutational and nonmutational activation of p21ras in rat colonic azoxymethane-induced tumors: effects on mitogen-activated protein kinase, cyclooxygenase-2, and cyclin D1.

Marc Bissonnette, Sharad Khare, F C von Lintig, +8

PubMed

Cyclin D1PathologyCox-2 ExpressionCancer BiologyTumor Biology +15

1,25 dihydroxyvitamin D3 stimulates phospholipase C-gamma in rat colonocytes: role of c-Src in PLC-gamma activation.

Sharad Khare, Merry J.G. Bolt, Ramesh K. Wali, +9

Journal of Clinical Investigation

Molecular PharmacologySignal TransductionMolecular PhysiologyGastrointestinal PharmacologyMembrane Transport +13

PKC-δ inhibits anchorage-dependent and -independent growth, enhances differentiation, and increases apoptosis in CaCo-2 cells

Marc Bissonnette, B. Scaglione-Sewell, Matthew R. Lyons, +3

Gastroenterology

Caco-2 CellsSignal TransductionMolecular PhysiologyPkc-δ InhibitsSignaling Pathway +11

Sprouty-2 controls c-Met expression and metastatic potential of colon cancer cells: sprouty/c-Met upregulation in human colonic adenocarcinomas

Cory Holgren, Urszula Dougherty, Francis Edwin, +6

Oncogene

Tumor BiologyOncologyOncogenic AgentMedicineColon Cancer Cells +7

Ursodeoxycholic Acid Suppresses Cox-2 Expression in Colon Cancer: Roles of Ras, p38, and CCAAT/Enhancer-Binding Protein

Sharad Khare, Reba Mustafi, Weihua Yuan, +13

Nutrition and Cancer

Ursodeoxycholic acid inhibits Ras mutations, wild-type Ras activation, and cyclooxygenase-2 expression in colon cancer.

Sharad Khare, Ramesh K. Wali, Friederike C. von Lintig, +9

PubMed

Cox-2 MrnaCyclooxygenase-2 ExpressionOncologyCox-2 InhibitionChemoprevention Strategy +13