Emanuele M. Gargano

Discovery of a new class of bicyclic substituted hydroxyphenylmethanones as 17β-hydroxysteroid dehydrogenase type 2 (17β-HSD2) inhibitors for the treatment of osteoporosis

Marie Wetzel, Emanuele M. Gargano, Stefan Hinsberger et al. · European Journal of Medicinal Chemistry · 2011 · 25 citations · Full text

Medicinal Chemistry, Biochemistry, Medicine +8

Discovery of a Novel Potent and Selective HSD17B13 Inhibitor, BI-3231, a Well-Characterized Chemical Probe Available for Open Science

Sven Thamm, Marina K. Willwacher, Gary E. Aspnes et al. · Journal of Medicinal Chemistry · 2023 · 18 citations · Full text

Novel, potent and selective 17β-hydroxysteroid dehydrogenase type 2 inhibitors as potential therapeutics for osteoporosis with dual human and mouse activities

Enrico Perspicace, Liliana Cozzoli, Emanuele M. Gargano et al. · European Journal of Medicinal Chemistry · 2014 · 17 citations · Full text

Medicinal Chemistry, Dual Human, Biochemistry +11

Metabolic stability optimization and metabolite identification of 2,5-thiophene amide 17β-hydroxysteroid dehydrogenase type 2 inhibitors

Emanuele M. Gargano, Enrico Perspicace, Nina Hanke et al. · European Journal of Medicinal Chemistry · 2014 · 17 citations · Full text

Biochemistry, Medicine, Rational Drug Design +8

Towards the evaluation in an animal disease model: Fluorinated 17β-HSD1 inhibitors showing strong activity towards both the human and the rat enzyme

Ahmed S. Abdelsamie, Emmanuel Bey, Emanuele M. Gargano et al. · European Journal of Medicinal Chemistry · 2015 · 12 citations · Full text

Animal Disease Model, 17β-Hsd1 Inhibitors, Biochemistry +6