Thomas Macartney

PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65

Chandana Kondapalli, Agne Kazlauskaite, Ning Zhang et al. · Open Biology · 2012 · 922 citations · Full text

Mitophagy, Molecular Biology, Insect Pink1 +16

14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localization

R. Jeremy Nichols, Nicolas Dzamko, Nicholas A. Morrice et al. · Biochemical Journal · 2010 · 397 citations · Full text

Neurodegenerative Diseases, Mitophagy, Signal Transduction +15

Coordination of Structure-Specific Nucleases by Human SLX4/BTBD12 Is Required for DNA Repair

Iván Muñoz, Karolina Hain, Anne‐Cécile Déclais et al. · Molecular Cell · 2009 · 332 citations · Full text

Chromatin, Genome Instability, Medicine +7

Identification of KIAA1018/FAN1, a DNA Repair Nuclease Recruited to DNA Damage by Monoubiquitinated FANCD2

Craig MacKay, Anne‐Cécile Déclais, Cecilia Lundin et al. · Cell · 2010 · 314 citations · Full text

Chromatin, Genome Instability, Dna Damage +6

The CUL3–KLHL3 E3 ligase complex mutated in Gordon's hypertension syndrome interacts with and ubiquitylates WNK isoforms: disease-causing mutations in KLHL3 and WNK4 disrupt interaction

Akihito Ohta, Frances‐Rose Schumacher, Youcef Mehellou et al. · Biochemical Journal · 2013 · 219 citations · Full text

Hypertension Syndrome Interacts, Genetics, Immunology +16