Kerrie B. Spencer

Targeting Xist with compounds that disrupt RNA structure and X inactivation

Rodrigo Aguilar, Kerrie B. Spencer, Barry Kesner et al. · Nature · 2022 · 125 citations · Full text

X Inactivation, Engineering, Natural Sciences +7

Discovery of 1-Amino-5<i>H</i>-pyrido[4,3-<i>b</i>]indol-4-carboxamide Inhibitors of Janus Kinase 2 (JAK2) for the Treatment of Myeloproliferative Disorders

Jongwon Lim, Brandon M. Taoka, Ryan D. Otte et al. · Journal of Medicinal Chemistry · 2011 · 73 citations · Full text

Janus Kinase 2, Jak-stat Pathway Mediates, Pharmacotherapy +19

Discovery of a 5<i>H</i>-Benzo[4,5]cyclohepta[1,2-<i>b</i>]pyridin-5-one (MK-2461) Inhibitor of c-Met Kinase for the Treatment of Cancer

Jason D. Katz, James P. Jewell, David Guérin et al. · Journal of Medicinal Chemistry · 2011 · 60 citations · Full text

Tumor Biology, Aberrant C-met Signaling, Drug Target +14

Overcoming Mutagenicity and Ion Channel Activity: Optimization of Selective Spleen Tyrosine Kinase Inhibitors

J. Michael Ellis, Michael D. Altman, Alan Bass et al. · Journal of Medicinal Chemistry · 2015 · 27 citations · Full text

Core Scaffold, Drug Target, Ion Channel Activity +20

Structural insights on ligand recognition at the human leukotriene B4 receptor 1

Nairie Michaelian, Anastasiia Sadybekov, Élie Besserer‐Offroy et al. · Nature Communications · 2021 · 22 citations · Full text