Ryan D. Otte

An orally available non-nucleotide STING agonist with antitumor activity

Bo‐Sheng Pan, Samanthi A. Perera, Jennifer Piesvaux et al. · Science · 2020 · 609 citations

Antitumor Activity, Immunology, Immunoediting +19

Discovery of 1-Amino-5<i>H</i>-pyrido[4,3-<i>b</i>]indol-4-carboxamide Inhibitors of Janus Kinase 2 (JAK2) for the Treatment of Myeloproliferative Disorders

Jongwon Lim, Brandon M. Taoka, Ryan D. Otte et al. · Journal of Medicinal Chemistry · 2011 · 73 citations · Full text

Janus Kinase 2, Jak-stat Pathway Mediates, Pharmacotherapy +19

Discovery of MK-1084: An Orally Bioavailable and Low-Dose KRAS^G12C Inhibitor

Xiaoshen Ma, David L. Sloman, Ruchia Duggal et al. · Journal of Medicinal Chemistry · 2024 · 31 citations

Overcoming Mutagenicity and Ion Channel Activity: Optimization of Selective Spleen Tyrosine Kinase Inhibitors

J. Michael Ellis, Michael D. Altman, Alan Bass et al. · Journal of Medicinal Chemistry · 2015 · 27 citations · Full text

Core Scaffold, Drug Target, Ion Channel Activity +20

Efficacious Intermittent Dosing of a Novel JAK2 Inhibitor in Mouse Models of Polycythemia Vera

Manfred Kraus, Yuxun Wang, Dan Aleksandrowicz et al. · PLoS ONE · 2012 · 15 citations · Full text

Apoptosis, Immunology, Cell Death +21