Crystal Structure of the IMP-1 Metallo β-Lactamase from <i>Pseudomonas aeruginosa</i> and Its Complex with a Mercaptocarboxylate Inhibitor:  Binding Determinants of a Potent, Broad-Spectrum Inhibitor^,

N.O. Concha, Cheryl A. Janson, P. Rowling, +9

Biochemistry

Development of a robust flow cytometric assay for determining numbers of viable bacteria

Robert Jepras, J Carter, S. Pearson, +1

Applied and Environmental Microbiology

Membrane PotentialAnaerobic CulturingAntimicrobial SusceptibilityBiochemistryPathogen Detection +12

Discovery of a Novel and Potent Class of FabI-Directed Antibacterial Agents

David Payne, William H. Miller, Valerie Berry, +29

Antimicrobial Agents and Chemotherapy

Indole Naphthyridinones as Inhibitors of Bacterial Enoyl-ACP Reductases FabI and FabK

Mark A. Seefeld, William H. Miller, Kenneth A. Newlander, +17

Journal of Medicinal Chemistry

Bioorganic ChemistryChemical BiologyPharmaceutical ChemistryDrug ResistanceMedicinal Chemistry +18

Discovery of Aminopyridine-Based Inhibitors of Bacterial Enoyl-ACP Reductase (FabI)

William H. Miller, Mark A. Seefeld, Kenneth A. Newlander, +16

Journal of Medicinal Chemistry

Medicinal ChemistryPharmaceutical ChemistryBioorganic ChemistryAntibioticsBiochemistry +13

Identification of a Series of Tricyclic Natural Products as Potent Broad-Spectrum Inhibitors of Metallo-β-Lactamases

David Payne, Juan A. Hueso-Rodríguez, Helen Boyd, +13

Antimicrobial Agents and Chemotherapy

Rapid assessment of antibiotic effects on Escherichia coli by bis-(1,3-dibutylbarbituric acid) trimethine oxonol and flow cytometry

Robert Jepras, S. Pearson, M. J. Wilkinson

Antimicrobial Agents and Chemotherapy

Cfu AssaysHealth SciencesAntibioticsAntimicrobial SusceptibilityMedicine +11

The bacA gene, which determines bacitracin susceptibility in Streptococcus pneumoniae and Staphylococcus aureus, is also required for virulence The GenBank accession number for the sequence reported in this paper is AF228662.

Alison F. Chalker, Karen Ingraham, R. Dwayne Lunsford, +6

Microbiology

BacteriologyStaphylococcus AureusMolecular BiologyBaca GeneBacteriophage +17

Inhibition of metallo-β-lactamases by a series of thiol ester derivatives of mercaptophenylacetic acid

David Payne, John H. Bateson, Brian C. Gasson, +4

FEMS Microbiology Letters

Medicinal ChemistryPharmaceutical ChemistryBioorganic ChemistryBiochemistryNatural Sciences +13

The stereochemistry of the reaction of phosphonous and phosphinous halides with 1,3-dienes

Alan M. Bond, M. Green, S. Pearson

Journal of the Chemical Society B Physical Organic

HeterocyclicAlkene MetathesisBiochemistryNatural Sciences1,1-Dimethylphosphol-3-en Chloride +10