Thomas N. O’Connell

METABOLISM AND DISPOSITION OF VARENICLINE, A SELECTIVE α4β2 ACETYLCHOLINE RECEPTOR PARTIAL AGONIST, IN VIVO AND IN VITRO

R. Scott Obach, Anne E. Reed‐Hagen, Suzanne S Krueger et al. · Drug Metabolism and Disposition · 2005 · 200 citations

A Small-Molecule Anti-secretagogue of PCSK9 Targets the 80S Ribosome to Inhibit PCSK9 Protein Translation

Donna N. Petersen, Julie A. Hawkins, Wanida Ruangsiriluk et al. · Cell chemical biology · 2016 · 95 citations · Full text

Pcsk9 Targets, Protein Function, Signal Transduction +9

Integrating Intramolecular Hydrogen Bonding (IMHB) Considerations in Drug Discovery Using ΔlogP As a Tool

Marina Shalaeva, Giulia Caron, Yuriy A. Abramov et al. · Journal of Medicinal Chemistry · 2013 · 85 citations · Full text

Reliable δLogp, Drug Target, Computational δLogp +19

Solution-Based Indirect Affinity Selection Mass Spectrometry—A General Tool For High-Throughput Screening Of Pharmaceutical Compound Libraries

Thomas N. O’Connell, Jason T. Ramsay, Steven F. Rieth et al. · Analytical Chemistry · 2014 · 77 citations

Hit Identification, Biological Mass Spectrometry, Proprietary Compounds +25

IDENTIFICATION OF A NOVEL GLUTATHIONE ADDUCT OF DICLOFENAC, 4′-HYDROXY-2′-GLUTATHION-DESCHLORO-DICLOFENAC, UPON INCUBATION WITH HUMAN LIVER MICROSOMES

Li Yu, Yue Chen, Michael P. DeNinno et al. · Drug Metabolism and Disposition · 2005 · 67 citations