Pembrolizumab in combination with gemcitabine and cisplatin compared with gemcitabine and cisplatin alone for patients with advanced biliary tract cancer (KEYNOTE-966): a randomised, double-blind, placebo-controlled, phase 3 trial

Robin Kate Kelley, Makoto Ueno, Changhoon Yoo, +208

The Lancet

UrologySurgical OncologyGastrointestinal OncologyMedicineBiliary Cancer +3

Safety and activity of alectinib against systemic disease and brain metastases in patients with crizotinib-resistant ALK-rearranged non-small-cell lung cancer (AF-002JG): results from the dose-finding portion of a phase 1/2 study

Shirish M. Gadgeel, Leena Gandhi, Gregory J. Riely, +14

The Lancet Oncology

Phase 1/2Neuro-oncologyDose-finding PortionBrain MetastasesMedicine +7

A randomized controlled trial of licartin for preventing hepatoma recurrence after liver transplantation

Jing Xu, Zhongyang Shen, Xinguo Chen, +17

Hepatology

Anti-diabetic effects of luteolin and luteolin-7-<i>O</i>-glucoside on KK-<i>A</i><i>y</i>mice

Yanqing Zang, Kiharu Igarashi, Li Yu

Bioscience Biotechnology and Biochemistry

Anti-diabetic EffectsGlycobiologyInsulin SignalingOxidative StressMetabolic Syndrome +15

Entrectinib, a TRK/ROS1 inhibitor with anti-CNS tumor activity: differentiation from other inhibitors in its class due to weak interaction with P-glycoprotein

Holger Fischer, Mohammed Ullah, Cecile C. de la Cruz, +10

Neuro-Oncology

The potential insulin sensitizing and glucose lowering effects of a novel indole derivative in vitro and in vivo

Li Yu, Yang Yu

Pharmacological Research

Diabetes ManagementBiochemistryPotential Insulin SensitizingMedicineInsulin Management +7

IDENTIFICATION OF A NOVEL GLUTATHIONE ADDUCT OF DICLOFENAC, 4′-HYDROXY-2′-GLUTATHION-DESCHLORO-DICLOFENAC, UPON INCUBATION WITH HUMAN LIVER MICROSOMES

Li Yu, Yue Chen, Michael P. DeNinno, +2

Drug Metabolism and Disposition

Absorption, distribution, metabolism and excretion (ADME) of the ALK inhibitor alectinib: results from an absolute bioavailability and mass balance study in healthy subjects

Peter N. Morcos, Li Yu, Katrijn Bogman, +11

Xenobiotica

Cardioprotective effects of ingliforib, a novel glycogen phosphorylase inhibitor

W. Ross Tracey, Judith L. Treadway, William P. Magee, +11

American Journal of Physiology-Heart and Circulatory Physiology

Heart FailureCardiovascular DiseaseBiochemistryGlycogen StoresMedicine +12

Vitamin D levels are associated with metabolic syndrome in adolescents and young adults: The BCAMS study

Junling Fu, Lanwen Han, Yanglu Zhao, +6

Clinical Nutrition

Vitamin NutritionNutritionMetabolic SyndromeObesityBody Composition +10