Innate Immune Landscape in Early Lung Adenocarcinoma by Paired Single-Cell Analyses

Yonit Lavin, Soma Kobayashi, Andrew M. Leader, +26

Cell

Cancer ImmunosurveillancePaired Single-cell AnalysesSingle Cell SequencingMedicineImmunology +9

RAF/MEK/extracellular signal–related kinase pathway suppresses dendritic cell migration and traps dendritic cells in Langerhans cell histiocytosis lesions

Brandon Hogstad, Marie‐Luise Berres, Rikhia Chakraborty, +21

The Journal of Experimental Medicine

BRAFV600E-induced senescence drives Langerhans cell histiocytosis pathophysiology

Camille Bigenwald, Jessica Le Bérichel, C. Matthias Wilk, +24

Nature Medicine

Cell SignalingHistiocytosis PathophysiologyAutophagyCell DeathCellular Senescence +4

BCL2 Inhibition Reveals a Dendritic Cell–Specific Immune Checkpoint That Controls Tumor Immunosurveillance

Liwei Zhao, Peng Liu, Misha Mao, +20

Cancer Discovery

Overcoming T-cell exhaustion in LCH: PD-1 blockade and targeted MAPK inhibition are synergistic in a mouse model of LCH

Amel Sengal, Jessica Velazquez, Meryl Hahne, +13

Blood

A comprehensive analysis of Lymphoma‐associated haemophagocytic syndrome in a large French multicentre cohort detects some clues to improve prognosis

Camille Bigenwald, L. Fardet, Paul Coppo, +9

British Journal of Haematology

ImmunodeficienciesImmunologyPathologyImmunotherapyClinical Epidemiology +17

Circulating senescent myeloid cells infiltrate the brain and cause neurodegeneration in histiocytic disorders

C. Matthias Wilk, Flurin Cathomas, Orsolya Török, +27

Immunity

Neurodegenerative DiseasesMedicineImmunologyHematologyBrain-immune Interaction +11

Hodgkin lymphoma in adolescent and young adults: insights from an adult tertiary single-center cohort of 349 patients

Camille Bigenwald, Jacques‐Emmanuel Galimard, L. Quéro, +4

Oncotarget

Gut Microbiota Modulation through <i>Akkermansia</i> spp <i>.</i> Supplementation Increases CAR T-cell Potency

Laura Marcos-Kovandzic, Michele Avagliano, Myriam Ben Khelil, +28

Cancer Discovery

CD8+ T Lymphocytes Immune Depletion and LAG-3 Overexpression in Hodgkin Lymphoma Tumor Microenvironment Exposed to Anti-PD-1 Immunotherapy

Jean‐Marie Michot, Séverine Mouraud, Julien Adam, +12

Cancers