Sonsoles Velázquez

1,2,3-Triazole-[2,5-Bis-O-(tert-butyldimethylsilyl)-.beta.-D-ribofuranosyl]-3'-spiro-5''-(4''-amino-1'',2''-oxathiole 2'',2''-dioxide) (TSAO) Analogs: Synthesis and Anti-HIV-1 Activity

Rosa Álvarez, Sonsoles Velázquez, Ana San‐Félix et al. · Journal of Medicinal Chemistry · 1994 · 750 citations

Pharmacy, Medicinal Chemistry, Pharmacology +13

Regiospecific Synthesis and Anti-Human Immunodeficiency Virus Activity of Novel 5-Substituted <i>N</i>-Alkylcarbamoyl and <i>N,N</i>-Dialkyl Carbamoyl 1,2,3-Triazole-TSAO Analogues

Sonsoles Velázquez, Rosa Álvarez, Carlos A. Perez et al. · Antiviral chemistry & chemotherapy · 1998 · 224 citations

Pharmacy, Chemistry, Medicinal Chemistry +13

Potent and Selective Inhibition of Varicella-Zoster Virus (VZV) by Nucleoside Analogues with an Unusual Bicyclic Base

Christopher McGuigan, Christopher J. Yarnold, Garry Jones et al. · Journal of Medicinal Chemistry · 1999 · 187 citations

Pharmacy, Medicinal Chemistry, Pharmacology +15

Characterization of the Activation Pathway of Phosphoramidate Triester Prodrugs of Stavudine and Zidovudine

Didier Saboulard, Lieve Naesens, Dominique Cahard et al. · Molecular Pharmacology · 1999 · 111 citations

Medicine, Medicinal Chemistry, Pharmacology +17

Resistance of HIV-1 reverse transcriptase against [2',5'-bis-O-(tert-butyldimethylsilyl)-3'-spiro-5“-(4”-amino-1“,2”- oxathiole-2“,2”-dioxide)] (TSAO) derivatives is determined by the mutation Glu138–&gt;Lys on the p51 subunit.

Heidi Jonckheere, Jean‐Marc Taymans, Jan Balzarini et al. · Journal of Biological Chemistry · 1994 · 90 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17