Ana San‐Félix

1,2,3-Triazole-[2,5-Bis-O-(tert-butyldimethylsilyl)-.beta.-D-ribofuranosyl]-3'-spiro-5''-(4''-amino-1'',2''-oxathiole 2'',2''-dioxide) (TSAO) Analogs: Synthesis and Anti-HIV-1 Activity

Rosa Álvarez, Sonsoles Velázquez, Ana San‐Félix et al. · Journal of Medicinal Chemistry · 1994 · 750 citations

Pharmacy, Medicinal Chemistry, Pharmacology +13

2',5'-Bis-O-(tert-butyldimethylsilyl)-3'-spiro-5''-(4''-amino-1'',2''- oxathiole-2'',2'-dioxide)pyrimidine (TSAO) nucleoside analogues: highlyselective inhibitors of human immunodeficiency virus type 1 that are targeted at the viral reverse transcriptase.

Jan Balzarini, María‐Jesús Pérez‐Pérez, Ana San‐Félix et al. · Proceedings of the National Academy of Sciences · 1992 · 162 citations

Medicine, Medicinal Chemistry, Pharmacology +17

3'-Spiro nucleosides, a new class of specific human immunodeficiency virus type 1 inhibitors: synthesis and antiviral activity of [2', 5'-bis-O-(tert-butyldimethylsilyl)-.beta.-D-xylo- and -ribofuranose]-3'-spiro-5''-[4''-amino-1'', 2''-oxathiole 2'', 2''-dioxide] (TSAO) pyrimidine nucleosides

María‐José Camarasa, María‐Jesús Pérez‐Pérez, Ana San‐Félix et al. · Journal of Medicinal Chemistry · 1992 · 129 citations

Pharmacy, Medicinal Chemistry, Drug Discovery +9

Kinetics of inhibition of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase by the novel HIV-1-specific nucleoside analogue [2',5'-bis-O-(tert-butyldimethylsilyl)-beta-D-ribofuranosyl]-3'-spiro-5 “- (4”-amino-1“,2”-oxathiole-2“,2”-dioxide)thymine (TSAO-T).

Jan Balzarini, María‐Jesús Pérez‐Pérez, Ana San‐Félix et al. · Journal of Biological Chemistry · 1992 · 119 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +13

TSAO analogs. Stereospecific synthesis and anti-HIV-1 activity of 1-[2',5'-bis-O-(tert-butyldimethylsilyl)-.beta.-D-ribofuranosyl]-3'-spiro-5''-(4''-amino-1'',2''-oxathiole-2'',2''-dioxide)pyrimidine and pyrimidine-modified nucleosides

María‐Jesús Pérez‐Pérez, Ana San‐Félix, Jan Balzarini et al. · Journal of Medicinal Chemistry · 1992 · 91 citations

Pharmacy, Chemistry, Medicinal Chemistry +13