James W. Malecha

Synthesis and Biological Evaluation of the 1,5-Diarylpyrazole Class of Cyclooxygenase-2 Inhibitors:  Identification of 4-[5-(4-Methylphenyl)-3- (trifluoromethyl)-1<i>H</i>-pyrazol-1-yl]benzenesulfonamide (SC-58635, Celecoxib)

Thomas D. Penning, John J. Talley, Stephen R. Bertenshaw et al. · Journal of Medicinal Chemistry · 1997 · 2K citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

B-[3-((Diisopropylamino)dimethylsilyl)allyl]diisopinocampheylborane: an excellent reagent for the stereoselective synthesis of anti vicinal diols

Anthony G. M. Barrett, James W. Malecha · The Journal of Organic Chemistry · 1991 · 73 citations

Natural Sciences, Chemistry, Organic Chemistry +5

KD5170, a novel mercaptoketone-based histone deacetylase inhibitor that exhibits broad spectrum antitumor activity <i>in vitro</i> and <i>in vivo</i>

Christian A. Hassig, Kent T. Symons, Xin Guo et al. · Molecular Cancer Therapeutics · 2008 · 43 citations

Medicine, Oncology, Pharmacology +14

Applications of crotyldiisopinocampheylboranes in synthesis: a formal total synthesis of (+)-calyculin A

Oren P. Anderson, Anthony G. M. Barrett, Jeremy J. Edmunds et al. · Canadian Journal of Chemistry · 2001 · 40 citations

Natural Sciences, Chemistry, Medicinal Chemistry +15

Synthesis of Potent Leukotriene A₄ Hydrolase Inhibitors. Identification of 3-[Methyl[3-[4-(phenylmethyl)phenoxy]propyl]amino]propanoic Acid

Thomas D. Penning, Mark A. Russell, Barbara B. Chen et al. · Journal of Medicinal Chemistry · 2002 · 39 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17