Hiroshi Tokumitsu

KN-62, 1-[N,O-bis(5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenylpiperazi ne, a specific inhibitor of Ca2+/calmodulin-dependent protein kinase II.

Hiroshi Tokumitsu, Takashi Chijiwa, Masatoshi Hagiwara et al. · Journal of Biological Chemistry · 1990 · 625 citations · Full text

Specific Inhibitor, Molecular Biology, Pharmacotherapy +23

Calcium promotes cell survival through CaM-K kinase activation of the protein-kinase-B pathway

Shigetoshi Yano, Hiroshi Tokumitsu, Thomas R. Soderling · Nature · 1998 · 616 citations

Signal Transduction, Cam-k Kinase Activation, Cell Regulation +14

Regulation of mitogen-activated protein kinases by a calcium/calmodulin-dependent protein kinase cascade.

Hervé Enslen, Hiroshi Tokumitsu, Philip A. Stork et al. · Proceedings of the National Academy of Sciences · 1996 · 293 citations · Full text

STO-609, a Specific Inhibitor of the Ca2+/Calmodulin-dependent Protein Kinase Kinase

Hiroshi Tokumitsu, Hiroyuki Inuzuka, Yumi Ishikawa et al. · Journal of Biological Chemistry · 2002 · 285 citations · Full text

A novel target recognition revealed by calmodulin in complex with Ca2+-calmodulin-dependent kinase kinase.

Mitsuhiko Ikura, Masanori Osawa, Hiroshi Tokumitsu et al. · Nature Structural Biology · 1999 · 239 citations

Molecular Pharmacology, Molecular Physiology, Signal Transduction +13