David Ortega-Alarcón

Structural stability of SARS-CoV-2 3CLpro and identification of quercetin as an inhibitor by experimental screening

Olga Abián, David Ortega-Alarcón, Ana Jiménez-Alesanco et al. · International Journal of Biological Macromolecules · 2020 · 281 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +11

Rutin Is a Low Micromolar Inhibitor of SARS-CoV-2 Main Protease 3CLpro: Implications for Drug Design of Quercetin Analogs

Bruno Rizzuti, Fedora Grande, Filomena Conforti et al. · Biomedicines · 2021 · 89 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Seleno-Functionalization of Quercetin Improves the Non-Covalent Inhibition of Mpro and Its Antiviral Activity in Cells against SARS-CoV-2

Francesca Mangiavacchi, Paweł Botwina, Elena Menichetti et al. · International Journal of Molecular Sciences · 2021 · 67 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +15

MEP pathway products allosterically promote monomerization of deoxy-D-xylulose-5-phosphate synthase to feedback-regulate their supply

Xueni Di, David Ortega-Alarcón, Ramu Kakumanu et al. · Plant Communications · 2022 · 45 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

Discovery of Diverse Natural Products as Inhibitors of SARS-CoV-2 M^pro Protease through Virtual Screening

J. Rubio, Ana Jiménez-Alesanco, Laura Ceballos-Laita et al. · Journal of Chemical Information and Modeling · 2021 · 30 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17