Leo Lap-Yan Wong

Oncogenic BRAF Is Required for Tumor Growth and Maintenance in Melanoma Models

Klaus P. Hoeflich, Daniel C. Gray, Michael Eby et al. · Cancer Research · 2006 · 232 citations

Cancer Biology, Tumor Biology, Oncogenic Braf +17

AMPK Promotes p53 Acetylation via Phosphorylation and Inactivation of SIRT1 in Liver Cancer Cells

Chi Wai Lee, Leo Lap-Yan Wong, Edith Yuk-Ting Tse et al. · Cancer Research · 2012 · 213 citations · Full text

Antitumor Efficacy of the Novel RAF Inhibitor GDC-0879 Is Predicted by BRAFV600E Mutational Status and Sustained Extracellular Signal-Regulated Kinase/Mitogen-Activated Protein Kinase Pathway Suppression

Klaus P. Hoeflich, Sylvia Herter, Janet Tien et al. · Cancer Research · 2009 · 172 citations · Full text

Tumor Biology, Melanoma Tumors, Oncogenic Activation +14

Pharmacodynamics of 2-{4-[(1E)-1-(Hydroxyimino)-2,3-dihydro-1H-inden-5-yl]-3-(pyridine-4-yl)-1H-pyrazol-1-yl}ethan-1-ol (GDC-0879), a Potent and Selective B-Raf Kinase Inhibitor: Understanding Relationships between Systemic Concentrations, Phosphorylated Mitogen-Activated Protein Kinase Kinase 1 Inhibition, and Efficacy

Harvey Wong, Marcia Belvin, Sylvia Herter et al. · Journal of Pharmacology and Experimental Therapeutics · 2009 · 50 citations

IPA-3 Inhibits the Growth of Liver Cancer Cells By Suppressing PAK1 and NF-κB Activation

Leo Lap-Yan Wong, Ian P. Y. Lam, Tracy Yuk-Nar Wong et al. · PLoS ONE · 2013 · 48 citations · Full text

Chemoprevention Strategy, Immunology, Cancer Biology +21